2-amino-2'-bromo-5-methyl-1,1'-biphenyl-4-ol 4-methylbenzenesulfonate ester

Base Information

• Chemical Name: 2-amino-2'-bromo-5-methyl-1,1'-biphenyl-4-ol 4-methylbenzenesulfonate ester
• CAS No.: 1025389-21-2
• Molecular Formula: C₂₀H₁₈BrNO₃S
• Molecular Weight: 432.338
• Mol file: 1025389-21-2.mol

Synonyms:2-amino-2'-bromo-5-methyl-1,1'-biphenyl-4-ol 4-methylbenzenesulfonate ester

Chemical Property of 2-amino-2'-bromo-5-methyl-1,1'-biphenyl-4-ol 4-methylbenzenesulfonate ester

Chemical Property:

Purity/Quality:

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Technology Process of 2-amino-2'-bromo-5-methyl-1,1'-biphenyl-4-ol 4-methylbenzenesulfonate ester

There total 1 articles about 2-amino-2'-bromo-5-methyl-1,1'-biphenyl-4-ol 4-methylbenzenesulfonate ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-amino-4-iodo-2-methylphenol 4-methylbenzenesulfonate ester (1025389-16-5) + (2-bromophenyl)boronic acid (244205-40-1) → 2-amino-2'-bromo-5-methyl-1,1'-biphenyl-4-ol 4-methylbenzenesulfonate ester (1025389-21-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; benzene; for 3h; Inert atmosphere; Reflux;

DOI:10.1021/ol800602v

Reference yield: 92.0%

2-amino-2'-bromo-5-methyl-1,1'-biphenyl-4-ol 4-methylbenzenesulfonate ester (1025389-21-2) → 2,2'-dibromo-5-methyl-1,1'-biphenyl-4-ol 4-methylbenzenesulfonate ester (1025389-25-6)

Guidance literature:

2-amino-2'-bromo-5-methyl-1,1'-biphenyl-4-ol 4-methylbenzenesulfonate ester; With sodium nitrite; In sulfuric acid; acetic acid; at 0 - 20 ℃;

With hydrogen bromide; copper(I) bromide; In sulfuric acid; water; acetic acid; at 80 ℃; for 4h;

DOI:10.1021/ol800602v

upstream raw materials:

5-amino-4-iodo-2-methylphenol 4-methylbenzenesulfonate ester

(2-bromophenyl)boronic acid

Downstream raw materials:

2,2'-dibromo-5-methyl-1,1'-biphenyl-4-ol 4-methylbenzenesulfonate ester

Refernces