C₄₅H₃₇F₂N₅O₇

Base Information

• Chemical Name: C₄₅H₃₇F₂N₅O₇
• CAS No.: 1613589-66-4
• Molecular Formula: C₄₅H₃₇F₂N₅O₇
• Molecular Weight: 797.815
• Mol file: 1613589-66-4.mol

Synonyms:C₄₅H₃₇F₂N₅O₇

Chemical Property of C₄₅H₃₇F₂N₅O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₅H₃₇F₂N₅O₇

There total 13 articles about C₄₅H₃₇F₂N₅O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

sodium benzoate (532-32-1) + C38H32F2IN5O5 (1613589-65-3) → C45H37F2N5O7 (1613589-66-4)

Guidance literature:

With 15-crown-5; In N,N-dimethyl-formamide; at 100 ℃; for 48h;

Reference yield:

((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate (874638-80-9,1033394-94-3) → C45H37F2N5O7 (1613589-66-4)

Guidance literature:

Multi-step reaction with 9 steps

1.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 1 h / -78 - -20 °C / Inert atmosphere

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.33 h / -25 - -20 °C / Inert atmosphere

3.1: potassium tert-butylate / acetonitrile; tert-butyl alcohol / 0.5 h / 35 °C

3.2: 50 °C

4.1: silver nitrate / dichloromethane / 20 °C

4.2: 12 h / 20 °C

5.1: triphenylphosphine; pyridine; iodine / 20 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 4 h / Reflux

7.1: triethylamine tris(hydrogen fluoride); N-iodo-succinimide / acetonitrile / 2 h / 20 °C / Cooling with ice

8.1: pyridine / 3 h / 0 - 20 °C

9.1: 15-crown-5 / N,N-dimethyl-formamide / 48 h / 100 °C

With pyridine; N-iodo-succinimide; 15-crown-5; carbon tetrabromide; potassium tert-butylate; iodine; silver nitrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine tris(hydrogen fluoride); lithium tri-t-butoxyaluminum hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

(((2R,3R,4R,5R)-3-(benzoyloxy)-5-bromo-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate) (1199809-24-9) → C45H37F2N5O7 (1613589-66-4)

Guidance literature:

Multi-step reaction with 7 steps

1.1: potassium tert-butylate / acetonitrile; tert-butyl alcohol / 0.5 h / 35 °C

1.2: 50 °C

2.1: silver nitrate / dichloromethane / 20 °C

2.2: 12 h / 20 °C

3.1: triphenylphosphine; pyridine; iodine / 20 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 4 h / Reflux

5.1: triethylamine tris(hydrogen fluoride); N-iodo-succinimide / acetonitrile / 2 h / 20 °C / Cooling with ice

6.1: pyridine / 3 h / 0 - 20 °C

7.1: 15-crown-5 / N,N-dimethyl-formamide / 48 h / 100 °C

With pyridine; N-iodo-succinimide; 15-crown-5; potassium tert-butylate; iodine; silver nitrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine tris(hydrogen fluoride); triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

upstream raw materials:

sodium benzoate

C₃₈H₃₂F₂IN₅O₅

((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate

(((2R,3R,4R,5R)-3-(benzoyloxy)-5-bromo-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate)

Downstream raw materials:

C₃₁H₂₉F₂N₅O₅