N-isopropyl-3-nitropyridin-2-amine

Base Information

• Chemical Name: N-isopropyl-3-nitropyridin-2-amine
• CAS No.: 26820-67-7
• Molecular Formula: C₈H₁₁N₃O₂
• Molecular Weight: 181.194
• Hs Code.: 2933399090
• Mol file: 26820-67-7.mol

Synonyms:Pyridine,2-(isopropylamino)-3-nitro- (8CI);3-Nitro-N-(propan-2-yl)pyridin-2-amine;N-Isopropyl-3-nitropyridin-2-amine;(Methylethyl)(3-nitro(2-pyridyl))amine;

Chemical Property of N-isopropyl-3-nitropyridin-2-amine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.59
• Boiling Point: 303.183 °C at 760 mmHg
• PKA: 2.70±0.10(Predicted)
• Flash Point: 137.161 °C
• PSA: 70.74000
• Density: 1.23 g/cm³
• LogP: 2.40630
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

N-Isopropyl-3-nitropyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-isopropyl-3-nitropyridin-2-amine

There total 3 articles about N-isopropyl-3-nitropyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) + isopropylamine (75-31-0) → 2-isopropylamino-3-nitropyridine (26820-67-7)

Guidance literature:

In N,N-dimethyl-formamide; at 40 ℃; for 6h;

DOI:10.1007/s007060200037

Reference yield:

2-bromo-3-nitropyridine (19755-53-4) + isopropylamine (75-31-0) → 2-isopropylamino-3-nitropyridine (26820-67-7)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.202010958

Reference yield:

→ 2-isopropylamino-3-nitropyridine (26820-67-7)

Guidance literature:

entspr. Hydroxypyridin, entspr. NH2-Verb., Subst.;

upstream raw materials:

2-Chloro-3-nitropyridine

isopropylamine

2-bromo-3-nitropyridine

Downstream raw materials:

3-amino-2-isopropylamino-pyridine