2-Bromo-3-nitropyridine

Base Information

• Chemical Name: 2-Bromo-3-nitropyridine
• CAS No.: 19755-53-4
• Molecular Formula: C5H3BrN2O2
• Molecular Weight: 202.995
• Hs Code.: 29333990
• Mol file: 19755-53-4.mol

Synonyms:3-Nitro-2-bromopyridine;

Chemical Property of 2-Bromo-3-nitropyridine

Chemical Property:

• Appearance/Colour: off-white to cream crystalline powder
• Vapor Pressure: 0.0485mmHg at 25°C
• Melting Point: 122-125 °C(lit.)
• Refractive Index: 1.614
• Boiling Point: 244 °C at 760 mmHg
• PKA: -3.24±0.10(Predicted)
• Flash Point: 101.4 °C
• PSA: 58.71000
• Density: 1.833 g/cm³
• LogP: 2.27550
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%, ^*data from raw suppliers

2-Bromo-3-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-36/37/39-22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Bromo-3-nitropyridine may be used in the synthesis of the following:3-nitropyridine-2-carbonitrilepyrrolo[3,2-b]pyridine3-(hetero)arylated phenothiazines7-anilino-6-azaindole-1-benznesulfonamides

Technology Process of 2-Bromo-3-nitropyridine

There total 6 articles about 2-Bromo-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

trifluoromethanesulfonic acid 3-nitropyridin-2-yl ester → 2-bromo-3-nitropyridine (19755-53-4)

Guidance literature:

With tetrabutylammomium bromide; In toluene; for 24h; Heating;

Reference yield: 52.0%

3-nitropyridine-2-carboxylic acid (59290-85-6) → 2-bromo-3-nitropyridine (19755-53-4)

Guidance literature:

With N-Bromosuccinimide; tert-butylhypochlorite; dichloromethane; oxygen; sodium hydrogencarbonate; at 70 ℃; for 20h; Green chemistry;

DOI:10.1039/c9gc02407g

Reference yield: 45.0%

2-amino-3-nitropyridine (4214-75-9) → 2-bromo-3-nitropyridine (19755-53-4)

Guidance literature:

With potassium nitrite; hydrogen bromide; copper(I) bromide; In water; dimethyl sulfoxide; at 35 ℃; for 4h;

DOI:10.1016/j.ejmech.2012.10.006

upstream raw materials:

2-hydroxy-3-nitropyridine

2-amino-3-nitropyridine

6-bromopyridin-3-ylboronic acid

3-nitropyridine-2-carboxylic acid

Downstream raw materials:

3-amino-2-bromopyridine

3-(3-nitropyridin-2-yl)-4-thiophenecarbaldehyde

3-nitro-2-[2-(trimethylsilyl)ethynyl]pyridine

3-nitropyridine-2-carbonitrile