3-ETHYL-2-HYDROXYQUINOLINE

Base Information

• Chemical Name: 3-ETHYL-2-HYDROXYQUINOLINE
• CAS No.: 2217-31-4
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 173.214
• Hs Code.: 2933790090
• Mol file: 2217-31-4.mol

Synonyms:Carbostyril,3-ethyl- (8CI); 3-Ethyl-2(1H)-quinolinone

Chemical Property of 3-ETHYL-2-HYDROXYQUINOLINE

Chemical Property:

• Vapor Pressure: 1.77E-05mmHg at 25°C
• Refractive Index: 1.644
• Boiling Point: 353.3°Cat760mmHg
• Flash Point: 167.5°C
• PSA: 33.12000
• Density: 1.17g/cm³
• LogP: 2.50280

Purity/Quality:

98%Min ^*data from raw suppliers

3-ETHYL-2-HYDROXYQUINOLINE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-ETHYL-2-HYDROXYQUINOLINE

There total 8 articles about 3-ETHYL-2-HYDROXYQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

quinazoline (253-82-7) + butanoic acid anhydride (106-31-0) → 3-ethyl-2(1H)-quinolinone (2217-31-4)

Guidance literature:

for 2h; Heating;

Reference yield: 66.0%

3-methylcarbostyril (2721-59-7) → 3-ethyl-2(1H)-quinolinone (2217-31-4)

Guidance literature:

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; for 0.5h; Ambient temperature;

DOI:10.1016/0040-4020(95)00377-K

Reference yield: 66.0%

3-methylcarbostyril (2721-59-7) → 3-ethyl-2(1H)-quinolinone (2217-31-4)

Guidance literature:

With electrophilic reagent; In tetrahydrofuran; hexane; for 0.5h; Mechanism; Ambient temperature; regioselective substitution with different electrophiles;

DOI:10.1016/0040-4020(95)00377-K

upstream raw materials:

3-ethyl-3,4-dihydro-2(1H)-quinolinone

1-(phenylmethyl)butanoic acid

quinazoline

butanoic acid anhydride

Downstream raw materials:

C₁₃H₁₂ClNO₂

C₁₃H₁₂ClNO₂

Refernces

• 1、 Martin, Olga,Cuesta de la, Elena,Avendano, Carmen. "Electrophilic Substitution in 3- and 4-Methyl-2(1H)quinolinone through Metallated Species". . p. 7547 - 7554. Retrieved 2007/10/02.