4-acetylamino-5-chloro-N-(2,2-dimethyl-1,3-dioxan-5-yl)-2-methoxybenzamide

Base Information

Chemical Name:4-acetylamino-5-chloro-N-(2,2-dimethyl-1,3-dioxan-5-yl)-2-methoxybenzamide
CAS No.:186795-60-8
Molecular Formula:C₁₆H₂₁ClN₂O₅
Molecular Weight:356.806
Hs Code.:

Synonyms:4-acetylamino-5-chloro-N-(2,2-dimethyl-1,3-dioxan-5-yl)-2-methoxybenzamide

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Chemical Property of 4-acetylamino-5-chloro-N-(2,2-dimethyl-1,3-dioxan-5-yl)-2-methoxybenzamide

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Technology Process of 4-acetylamino-5-chloro-N-(2,2-dimethyl-1,3-dioxan-5-yl)-2-methoxybenzamide

There total 1 articles about 4-acetylamino-5-chloro-N-(2,2-dimethyl-1,3-dioxan-5-yl)-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4064-87-3
2,2-dimethyl-5-nitro-1,3-dioxane

: 186795-60-8
4-acetylamino-5-chloro-N-(2,2-dimethyl-1,3-dioxan-5-yl)-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / Fe, NH₄Cl / aq. ethanol / 2 h / Heating

2: 1.) N,N'-carbonyldiimidazole / 1.) DMF, RT, 1 h, 2.) DMF, RT, 18 h

With iron; ammonium chloride; 1,1'-carbonyldiimidazole; In ethanol;
DOI:10.1248/cpb.44.2205

Reference yield: 81.0%

: 186795-60-8
4-acetylamino-5-chloro-N-(2,2-dimethyl-1,3-dioxan-5-yl)-2-methoxybenzamide

: 4-acetylamino-5-chloro-N-(1,3-dihydroxy-2-propyl)-2-methoxybenzamide

Guidance literature:: With pyridinium p-toluenesulfonate; In methanol; for 48h; Ambient temperature;
DOI:10.1248/cpb.44.2205

Reference yield:

: 186795-60-8
4-acetylamino-5-chloro-N-(2,2-dimethyl-1,3-dioxan-5-yl)-2-methoxybenzamide

: 24190-73-6
4-Acetamido-5-chlor-2-methoxybenzamid

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / pyridinium p-toluenesulfonate / methanol / 48 h / Ambient temperature

2: 1.) DMSO, oxalyl chloride, 2.) Et₃N / 1.) CH₂Cl₂, -70 deg C, 20 min, 2.) CH₂Cl₂, - 70 deg C, 20 min

With oxalyl dichloride; pyridinium p-toluenesulfonate; dimethyl sulfoxide; triethylamine; In methanol;
DOI:10.1248/cpb.44.2205