(R)-2-methyl-3-(4-{4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl}phenoxy)propane-1,2-diol p-toluenesulfonic acid salt

Base Information

Chemical Name:(R)-2-methyl-3-(4-{4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl}phenoxy)propane-1,2-diol p-toluenesulfonic acid salt
CAS No.:1318735-09-9
Molecular Formula:C₇H₈O₃S*C₂₂H₂₆F₃NO₅
Molecular Weight:613.652
Hs Code.:

Synonyms:(R)-2-methyl-3-(4-{4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl}phenoxy)propane-1,2-diol p-toluenesulfonic acid salt

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Chemical Property of (R)-2-methyl-3-(4-{4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl}phenoxy)propane-1,2-diol p-toluenesulfonic acid salt

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Technology Process of (R)-2-methyl-3-(4-{4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl}phenoxy)propane-1,2-diol p-toluenesulfonic acid salt

There total 2 articles about (R)-2-methyl-3-(4-{4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl}phenoxy)propane-1,2-diol p-toluenesulfonic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1318735-00-0
(R)-2-methyl-3-(4-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)phenoxy)propane-1,2-diol

: 104-15-4
toluene-4-sulfonic acid

: 1318735-09-9
(R)-2-methyl-3-(4-{4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl}phenoxy)propane-1,2-diol p-toluenesulfonic acid salt

Guidance literature:: In isopropyl alcohol; Industry scale;

Reference yield:

: 1318734-99-4
(R)-3-(4-bromophenoxy)-2-methylpropane-1,2-diol

: 1318735-09-9
(R)-2-methyl-3-(4-{4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl}phenoxy)propane-1,2-diol p-toluenesulfonic acid salt

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide; tributyl-amine / 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / xylene / 21 h / 80 °C / Inert atmosphere

2: isopropyl alcohol / Industry scale

With tributyl-amine; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In isopropyl alcohol; xylene;

Reference yield: 86.7%

: 1318735-09-9
(R)-2-methyl-3-(4-{4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl}phenoxy)propane-1,2-diol p-toluenesulfonic acid salt

: 1083099-35-7
(R)-1-(4-((2-methyloxiran-2-yl)-methoxy)phenyl)-4-(4-(trifluoro-methoxy)phenoxy)piperidine

Guidance literature:: (R)-2-methyl-3-(4-{4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl}phenoxy)propane-1,2-diol p-toluenesulfonic acid salt; With methanesulfonyl chloride; triethylamine; In cyclopentyl methyl ether; at 5 ℃; Industry scale;

With sodium hydroxide; In cyclopentyl methyl ether; water; at 40 ℃; for 1.5h;