1083099-35-7

Upstream product

• 287952-67-4 4-(4-(trifluoromethoxy)phenoxy)piperidine 
• 65214-82-6 4-hydroxy-piperidine-1-carboxylic acid ethyl ester 
• 828-27-3 4-Trifluoromethoxyphenol 
• 540-38-5 p-Iodophenol 
• 681482-80-4 1-[4-(tetrahydropyran-2-yloxy)phenyl]-4-(4-trifluoromethoxyphenoxy)piperidine 
• 36603-49-3 4-(tetrahydropyran-2'-yloxy)-1-bromobenzene 
• 1318735-09-9 (R)-2-methyl-3-(4-{4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl}phenoxy)propane-1,2-diol p-toluenesulfonic acid salt 
• 1318735-00-0 (R)-2-methyl-3-(4-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)phenoxy)propane-1,2-diol 
• 1318734-99-4 (R)-3-(4-bromophenoxy)-2-methylpropane-1,2-diol 
• 683276-64-4 [(2R)-2-methyloxiran-2-yl]methyl 3-nitrobenzenesulfonate 
• 1083099-52-8 lithium 4-(4-(4-trifluoromethoxy-phenoxy)piperidin-1-yl)phenolate 
• 866109-93-5 4-(4-(4-trifluoromethoxy-phenoxy)piperidin-1-yl)phenol para-toluenesulfonic acid salt 
• 681482-81-5 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine 

Relevant academic research and scientific papers

A concise and sequential synthesis of the nitroimidazooxazole based drug, Delamanid and related compounds

A concise, protection-group free and sequential route has been developed for the synthesis of the nitroimidazole based FDA-approved multi-drug resistant anti-tuberculosis drug, Delamanid and anti-leishmanial lead candidate VL-2098. The synthesis required

PROCESS FOR THE PREPARATION OF DERIVATIVES OF 1,1-DIALKYLETHANE-1,2-DIOLS AS USEFUL INTERMEDIATES

The invention provides a novel and practical route of synthesis the substituted diol intermediates, 1,1-dialkylethane-1,2-diols, useful for the preparation of various 6-nitro-2,3-dihydroimidazo[2,1-b]oxazole containing drugs. Specifically, the invention p

METHOD FOR PRODUCING 1-(4-HYDROXYPHENYL)-4-(4-TRIFLUOROMETHOXYPHENOXY)PIPERIDINE OR SALT THEREOF

The present invention provides a method for producing 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine or a salt thereof, the method including the step of heating hydroquinone and 4-(4-trifluoromethoxyphenoxy)piperidine. This method can produce 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine or a salt thereof in an industrially advantageous manner.

Method for preparing Delmanid high-purity intermediate by one-pot method

The invention relates to a method for preparing a Delmanid high-purity intermediate by a one-pot method, and belongs to the technical field of chemical medicines. The preparation method comprises thefollowing steps: (1) carrying out a Buchwald-Hartwig ary

SYNTHETIC INTERMEDIATE OF OXAZOLE COMPOUND AND METHOD FOR PRODUCING THE SAME

An object of the present invention is to provide a method for producing an oxazole compound in a high yield. The object can be achieved by a compound represented by Formula (11): wherein R1 is a hydrogen atom or lower-alkyl group; R2

EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME

The present invention provides a novel intermediate for manufacturing a 2,3-dihydroimidazo[2,1-b]oxazole compound with a high yield and a high purity, and a manufacturing method of the intermediate. The present invention provides an epoxy compound represe