ethyl 1-[(4-methoxyphenyl)methyl]-5-[3-(trifluoromethoxy)phenoxy]-1H-1,2,3-triazole-4-carboxylate

Base Information

Chemical Name:ethyl 1-[(4-methoxyphenyl)methyl]-5-[3-(trifluoromethoxy)phenoxy]-1H-1,2,3-triazole-4-carboxylate
CAS No.:1607442-66-9
Molecular Formula:C₂₀H₁₈F₃N₃O₅
Molecular Weight:437.375
Hs Code.:

Synonyms:ethyl 1-[(4-methoxyphenyl)methyl]-5-[3-(trifluoromethoxy)phenoxy]-1H-1,2,3-triazole-4-carboxylate

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Chemical Property of ethyl 1-[(4-methoxyphenyl)methyl]-5-[3-(trifluoromethoxy)phenoxy]-1H-1,2,3-triazole-4-carboxylate

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Technology Process of ethyl 1-[(4-methoxyphenyl)methyl]-5-[3-(trifluoromethoxy)phenoxy]-1H-1,2,3-triazole-4-carboxylate

There total 5 articles about ethyl 1-[(4-methoxyphenyl)methyl]-5-[3-(trifluoromethoxy)phenoxy]-1H-1,2,3-triazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 827-99-6
3-(trifluoromethoxy)phenol

: 75020-42-7
ethyl 5-chloro-1-[(4-methoxyphenyl)methyl]-1H-1,2,3-triazole-4-carboxylate

: 1607442-66-9
ethyl 1-[(4-methoxyphenyl)methyl]-5-[3-(trifluoromethoxy)phenoxy]-1H-1,2,3-triazole-4-carboxylate

Guidance literature:: 3-(trifluoromethoxy)phenol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 23 ℃; for 0.75h;

ethyl 5-chloro-1-[(4-methoxyphenyl)methyl]-1H-1,2,3-triazole-4-carboxylate; In N,N-dimethyl-formamide; mineral oil; at 75 ℃; for 135h;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1607442-66-9
ethyl 1-[(4-methoxyphenyl)methyl]-5-[3-(trifluoromethoxy)phenoxy]-1H-1,2,3-triazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide / N,N-dimethyl-formamide / 15 h / 23 °C

2.1: sodium / ethanol / 24 h / Reflux

3.1: phosphorus pentachloride / toluene / 1.5 h / 40 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 23 °C

4.2: 135 h / 75 °C

With sodium azide; phosphorus pentachloride; sodium; sodium hydride; In ethanol; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 70978-37-9
1-(azidomethyl)-4-methoxybenzene

: 1607442-66-9
ethyl 1-[(4-methoxyphenyl)methyl]-5-[3-(trifluoromethoxy)phenoxy]-1H-1,2,3-triazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium / ethanol / 24 h / Reflux

2.1: phosphorus pentachloride / toluene / 1.5 h / 40 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 23 °C

3.2: 135 h / 75 °C

With phosphorus pentachloride; sodium; sodium hydride; In ethanol; N,N-dimethyl-formamide; toluene; mineral oil;