tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1S)-2-methoxy-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-(3-methyl-4-phenylphenyl)hexanoate

Base Information

Chemical Name:tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1S)-2-methoxy-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-(3-methyl-4-phenylphenyl)hexanoate
CAS No.:230961-86-1
Molecular Formula:C₃₉H₅₂N₂O₅
Molecular Weight:628.852
Hs Code.:

Synonyms:tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1S)-2-methoxy-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-(3-methyl-4-phenylphenyl)hexanoate

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Chemical Property of tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1S)-2-methoxy-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-(3-methyl-4-phenylphenyl)hexanoate

Chemical Property:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1S)-2-methoxy-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-(3-methyl-4-phenylphenyl)hexanoate

There total 25 articles about tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1S)-2-methoxy-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-(3-methyl-4-phenylphenyl)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 230962-30-8
tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-(carboxy)propyl]amino}carbonyl)-6-[3-methyl-(4-phenyl)phenyl]hexanoate

: 91298-74-7
(S)-2-methoxy-1-phenylethylamine

: 230961-86-1
tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1S)-2-methoxy-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-(3-methyl-4-phenylphenyl)hexanoate

Guidance literature:: With ((3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V); In dichloromethane; at 0 - 20 ℃; for 3.75h;

Reference yield:

: 5002-26-6
3-methyl-4-phenylbromobenzene

: 230961-86-1
tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1S)-2-methoxy-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-(3-methyl-4-phenylphenyl)hexanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: Mg; I₂ / tetrahydrofuran / Heating

1.2: 60 percent / tetrahydrofuran / -40 - 0 °C

2.1: Et₃SiH; TFA / 0 - 20 °C

3.1: (COCl)2; DMF / CH₂Cl₂ / -10 - 20 °C

4.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -70 - -50 °C

4.2: 91 percent / tetrahydrofuran; hexane / -70 - 0 °C

5.1: NaN(SiMe₃)2 / tetrahydrofuran / 1 h / -75 °C

5.2: 61 percent / tetrahydrofuran / -70 - -50 °C

6.1: 97 percent / aq. H₂O₂; LiOH / tetrahydrofuran / 0 - 20 °C

7.1: 99 percent / N-(dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; i-Pr₂NEt; 1-hydroxy-1,2,3-benzotriazole hydrate / CH₂Cl₂ / 4 - 20 °C

With triethylsilane; lithium hydroxide; n-butyllithium; oxalyl dichloride; dihydrogen peroxide; iodine; sodium hexamethyldisilazane; magnesium; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm0308038

Reference yield:

: 116632-39-4
2-methyl-4-bromoiodobenzene

: 230961-86-1
tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1S)-2-methoxy-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-(3-methyl-4-phenylphenyl)hexanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 79 percent / Pd(OAc)2; PPh₃; aq. Na₂CO₃ / acetone / 18 h / Heating

2.1: Mg; I₂ / tetrahydrofuran / Heating

2.2: 60 percent / tetrahydrofuran / -40 - 0 °C

3.1: Et₃SiH; TFA / 0 - 20 °C

4.1: (COCl)2; DMF / CH₂Cl₂ / -10 - 20 °C

5.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -70 - -50 °C

5.2: 91 percent / tetrahydrofuran; hexane / -70 - 0 °C

6.1: NaN(SiMe₃)2 / tetrahydrofuran / 1 h / -75 °C

6.2: 61 percent / tetrahydrofuran / -70 - -50 °C

7.1: 97 percent / aq. H₂O₂; LiOH / tetrahydrofuran / 0 - 20 °C

8.1: 99 percent / N-(dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; i-Pr₂NEt; 1-hydroxy-1,2,3-benzotriazole hydrate / CH₂Cl₂ / 4 - 20 °C

With triethylsilane; palladium diacetate; lithium hydroxide; n-butyllithium; oxalyl dichloride; dihydrogen peroxide; iodine; sodium hexamethyldisilazane; sodium carbonate; magnesium; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; acetone; 1.1: Suzuki reaction;
DOI:10.1021/jm0308038