3-hydroxy-2,3-diphenylpropionitrile

Base Information

• Chemical Name: 3-hydroxy-2,3-diphenylpropionitrile
• CAS No.: 71312-66-8
• Molecular Formula: C₁₅H₁₃NO
• Molecular Weight: 223.274
• Mol file: 71312-66-8.mol

Synonyms:3-hydroxy-2,3-diphenylpropionitrile

Chemical Property of 3-hydroxy-2,3-diphenylpropionitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-hydroxy-2,3-diphenylpropionitrile

There total 4 articles about 3-hydroxy-2,3-diphenylpropionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

trans-4,5-dihydro-4,5-diphenyl-3-(phenylsulfonyl)isoxazole (85355-68-6) → 3-hydroxy-2,3-diphenylpropionitrile (71312-66-8)

Guidance literature:

With sodium amalgam; In dichloromethane; for 0.5h; pH 7;

DOI:10.1021/jo00390a003

Reference yield:

benzaldehyde (100-52-7) + 3-hydroxy-2,5-diphenyl-3-methylpent-4-enenitrile (63064-12-0) → 3-hydroxy-2,3-diphenylpropionitrile (71312-73-7) + 3-hydroxy-2,3-diphenylpropionitrile (71312-66-8)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.0333333h; Title compound not separated from byproducts;

DOI:10.1021/jo0478050

Reference yield:

phenylacetonitrile (140-29-4) + benzaldehyde (100-52-7) → 3-hydroxy-2,3-diphenylpropionitrile (71312-73-7) + 3-hydroxy-2,3-diphenylpropionitrile (71312-66-8)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h; Product distribution; also with LiHMDS and Et₂O;

DOI:10.1021/jo00094a011

upstream raw materials:

trans-4,5-dihydro-4,5-diphenyl-3-(phenylsulfonyl)isoxazole

phenylacetonitrile

benzaldehyde

3-hydroxy-2,5-diphenyl-3-methylpent-4-enenitrile

Downstream raw materials:

(+/-)-threo-3-Amino-1,2-diphenyl-propanol-⁽¹⁾

(+/-)-threo-3-Dimethylamino-1,2-diphenyl-propanol-⁽¹⁾