2-(p-tolyl)ethynyl-4-methyl-6-phenyl-pyrimidine-5-carboxylic acid ethyl ester

Base Information

• Chemical Name: 2-(p-tolyl)ethynyl-4-methyl-6-phenyl-pyrimidine-5-carboxylic acid ethyl ester
• CAS No.: 1220560-28-0
• Molecular Formula: C₂₃H₂₀N₂O₂
• Molecular Weight: 356.424
• Mol file: 1220560-28-0.mol

Synonyms:2-(p-tolyl)ethynyl-4-methyl-6-phenyl-pyrimidine-5-carboxylic acid ethyl ester

Chemical Property of 2-(p-tolyl)ethynyl-4-methyl-6-phenyl-pyrimidine-5-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 2-(p-tolyl)ethynyl-4-methyl-6-phenyl-pyrimidine-5-carboxylic acid ethyl ester

There total 7 articles about 2-(p-tolyl)ethynyl-4-methyl-6-phenyl-pyrimidine-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

diethyl 2,2′-disulfanediylbis(6-methyl-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate) + 4-n-methylphenylacetylene (766-97-2) → 2-(p-tolyl)ethynyl-4-methyl-6-phenyl-pyrimidine-5-carboxylic acid ethyl ester (1220560-28-0)

Guidance literature:

With copper(I) thiophene-2-carboxylate; triethylamine; bis[2-(diphenylphosphino)phenyl] ether; In 5,5-dimethyl-1,3-cyclohexadiene; at 120 ℃; for 48h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tet.2015.09.022

Reference yield: 86.0%

ethyl 4-methyl-6-phenyl-2-(tosyloxy)pyrimidine-5-carboxylate (1245716-47-5) + 4-n-methylphenylacetylene (766-97-2) → 2-(p-tolyl)ethynyl-4-methyl-6-phenyl-pyrimidine-5-carboxylic acid ethyl ester (1220560-28-0)

Guidance literature:

With potassium phosphate; copper(I) thiophene-2-carboxylate; 1,3-bis-(diphenylphosphino)propane; In 1,4-dioxane; at 110 ℃; for 48h; Sealed tube; Inert atmosphere;

DOI:10.1039/c5ra09765g

Reference yield: 81.0%

ethyl 2-(ethylthio)-4-methyl-6-phenylpyrimidine-5-carboxylate + 4-n-methylphenylacetylene (766-97-2) → 2-(p-tolyl)ethynyl-4-methyl-6-phenyl-pyrimidine-5-carboxylic acid ethyl ester (1220560-28-0)

Guidance literature:

With copper(I) thiophene-2-carboxylate; bis[2-(diphenylphosphino)phenyl] ether; In 1,4-dioxane; at 110 ℃; for 48h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c5cy00802f

upstream raw materials:

ethyl 6-methyl-4-phenylpyrimidin-2(1H)-one-5-carboxylate

4-n-methylphenylacetylene

ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate

ethyl 2-hydroxy-4-methyl-6-phenylpyrimidine-5-carboxylate