1245716-47-5

Basic information

• Product Name: ethyl 4-methyl-6-phenyl-2-(tosyloxy)pyrimidine-5-carboxylate
• Synonyms: ethyl 4-methyl-6-phenyl-2-(tosyloxy)pyrimidine-5-carboxylate
• CAS NO: 1245716-47-5
• Molecular Weight: 412.466
• Mol File: 1245716-47-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 4-methyl-6-phenyl-2-(tosyloxy)pyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-methyl-6-phenyl-2-(tosyloxy)pyrimidine-5-carboxylate(1245716-47-5)
• EPA Substance Registry System: ethyl 4-methyl-6-phenyl-2-(tosyloxy)pyrimidine-5-carboxylate(1245716-47-5)

Safety Data

• Hazardous Substances Data: 1245716-47-5(Hazardous Substances Data)

Upstream product

• 123237-03-6 ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate 
• 69207-36-9 ethyl 2-hydroxy-4-methyl-6-phenylpyrimidine-5-carboxylate 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 928118-80-3 2-(piperidin-1-yl)-4-methyl-6-phenylpyrimidine-5-carboxylic acid ethyl ester 
• 1245716-69-1 2-ethoxy-4-methyl-6-phenylpyrimidine-5-carboxylic acid ethyl ester 
• 1245716-66-8 ethyl 2-(ethylamino)-4-methyl-6-phenylpyrimidine-5-carboxylate 
• 928118-84-7 ethyl 2-[(2-hydroxyethyl)amino]-4-methyl-6-phenylpyrimidine-5-carboxylate 
• 69207-36-9 ethyl 2-hydroxy-4-methyl-6-phenylpyrimidine-5-carboxylate 
• 599-89-3 4-chlorophenyl p-toluenesulfonate 
• 928119-13-5 ethyl 4-methyl-6-phenyl-2-(p-tolylthio)pyrimidine-5-carboxylate 
• 1245716-70-4 ethyl 2-isopropoxy-4-methyl-6-phenylpyrimidine-5-carboxylate 
• 1245716-71-5 ethyl 2-(benzyloxy)-4-methyl-6-phenylpyrimidine-5-carboxylate 
• 640-60-8 toluene-4-sulfonic acid phenyl ester 
• 80742-17-2 4-methyl-2,6-diphenyl-pyrimidine-5-carboxylic acid ethyl ester 
• 1048007-29-9 4-methyl-6-phenyl-2-p-tolyl-pyrimidine-5-carboxylic acid ethyl ester 
• 1220560-28-0 2-(p-tolyl)ethynyl-4-methyl-6-phenyl-pyrimidine-5-carboxylic acid ethyl ester 

Relevant articles and documents

4-aryl-pyrimidin-2-yl tosylates as efficient reaction partners: Application to the synthesis of pyrimidines functionalised with propargyloxy and 1,2,3-triazolo groups

The 4-arylated pyrimidin-2-yl tosylate derivatives, easily prepared from cheap commercial materials, reacted efficiently with propargyl alcohol/NaOBut to give the corresponding 4-arylated 2-propargyloxy-pyrimidine derivatives which, in a onepot

Synthesis of 2-substituted pyrimidines via cross-coupling reaction of pyrimidin-2-yl sulfonates with nucleophiles in polyethylene glycol 400

A mild and rapid procedure to the synthesis of 2-substituted pyrimidines was developed via sequential functionalization of easily available Biginelli 3,4-dihydropyrimidine-2(1H)-ones via oxidation, esterification, followed by cross-coupling reaction of pyrimidin-2-yl sulfonates with N, S, and O nucleophiles in PEG-400 as a green reaction medium at room temperature. Georg Thieme Verlag Stuttgart New York.