4-(1-oxidopyridin-4-yl)benzenesulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide

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Chemical Name:4-(1-oxidopyridin-4-yl)benzenesulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide
CAS No.:245761-14-2
Molecular Formula:C₂₃H₂₀N₄O₄S
Molecular Weight:448.502
Hs Code.:

Synonyms:4-(1-oxidopyridin-4-yl)benzenesulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide

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Chemical Property of 4-(1-oxidopyridin-4-yl)benzenesulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide

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Technology Process of 4-(1-oxidopyridin-4-yl)benzenesulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide

There total 6 articles about 4-(1-oxidopyridin-4-yl)benzenesulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 186551-74-6
4-pyridin-4-ylbenzenesulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide

: 245761-14-2
4-(1-oxidopyridin-4-yl)benzenesulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 20 ℃; for 18h;
DOI:10.1021/jm990041+

Reference yield:

: 39795-60-3
4-(4-bromophenyl)pyridine

: 245761-14-2
4-(1-oxidopyridin-4-yl)benzenesulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: t-BuLi / tetrahydrofuran; diethyl ether / -78 °C

1.2: SO₂(g) / diethyl ether / -78 - 20 °C

2.1: SO₂Cl₂ / hexane; CH₂Cl₂ / 4 h / 0 - 20 °C

3.1: Et₃N / acetonitrile / 4 h

4.1: 100 percent / 3-chloroperoxybenzoic acid / CHCl₃ / 18 h / 20 °C

With sulfuryl dichloride; tert.-butyl lithium; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; chloroform; acetonitrile; 1.1: Metallation / 1.2: Sulfination / 2.1: Chlorination / 3.1: Sulfonylation / 4.1: Oxidation;
DOI:10.1021/jm990041+

Reference yield:

: 1120-87-2
4-bromopyridin

: 245761-14-2
4-(1-oxidopyridin-4-yl)benzenesulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / tetrahydrofuran; pentane / 0.17 h / -78 °C

1.2: ZnCl₂ / tetrahydrofuran; diethyl ether; pentane / 2 h / -78 - 20 °C

1.3: 58 percent / Pd(PPh₃)4 / tetrahydrofuran / 72 h / 20 °C

2.1: t-BuLi / tetrahydrofuran; diethyl ether / -78 °C

2.2: SO₂(g) / diethyl ether / -78 - 20 °C

3.1: SO₂Cl₂ / hexane; CH₂Cl₂ / 4 h / 0 - 20 °C

4.1: Et₃N / acetonitrile / 4 h

5.1: 100 percent / 3-chloroperoxybenzoic acid / CHCl₃ / 18 h / 20 °C

With n-butyllithium; sulfuryl dichloride; tert.-butyl lithium; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; chloroform; acetonitrile; pentane; 1.1: Metallation / 1.2: Substitution / 1.3: Arylation / 2.1: Metallation / 2.2: Sulfination / 3.1: Chlorination / 4.1: Sulfonylation / 5.1: Oxidation;
DOI:10.1021/jm990041+