trans-4-Aminocyclohexanemethanol

Base Information

• Chemical Name: trans-4-Aminocyclohexanemethanol
• CAS No.: 1467-84-1
• Molecular Formula: C7H15NO
• Molecular Weight: 129.202
• Hs Code.: 2922199090
• Mol file: 1467-84-1.mol

Synonyms:(trans-4-Aminocyclohexyl)methanol;trans-4-Aminocyclohexanemethanol;((1R,4r)-4-aMinocyclohexyl)Methanol

Chemical Property of trans-4-Aminocyclohexanemethanol

Chemical Property:

• Appearance/Colour: White solid
• Melting Point: 146-148?C
• Refractive Index: 1.477
• Boiling Point: 218.796 °C at 760 mmHg
• PKA: 15.05±0.10(Predicted)
• Flash Point: 86.125 °C
• PSA: 46.25000
• Density: 0.974 g/cm³
• LogP: 1.19650
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Dichloromethane, Methanol

Purity/Quality:

99.3% ^*data from raw suppliers

trans 4-Aminocyclohexanemethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Metabolites of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea (Me CCNU)

Technology Process of trans-4-Aminocyclohexanemethanol

There total 15 articles about trans-4-Aminocyclohexanemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1r,4r)-ethyl 4-aminocyclohexanecarboxylate hydrochloride (2084-28-8,61367-17-7) → ((1r,4r)-4-aminocyclohexyl)methanol (1467-84-1)

Guidance literature:

(1r,4r)-ethyl 4-aminocyclohexanecarboxylate hydrochloride; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; Cooling with ice;

With sodium hydroxide; In water; at 20 ℃; for 0.5h; Cooling with ice;

Reference yield: 100.0%

(1 r,4r)-ethyl 4-aminocyclohexanecarboxylate hydrochloride (2084-28-8,61367-17-7) → ((1r,4r)-4-aminocyclohexyl)methanol (1467-84-1)

Guidance literature:

(1 r,4r)-ethyl 4-aminocyclohexanecarboxylate hydrochloride; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; Cooling with ice;

With sodium hydroxide; In water; for 0.5h; Cooling with ice;

Reference yield: 99.0%

ethyl trans-4-aminocyclohexanecarboxylate → ((1r,4r)-4-aminocyclohexyl)methanol (1467-84-1)

Guidance literature:

ethyl trans-4-aminocyclohexanecarboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃;

With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.5h;

upstream raw materials:

trans-4-aminocyclohexanecarboxylic acid ethyl ester hydrochloride

trans-4-aminocyclohexanecarboxylic acid

trans-hexahydroterephthalic acid

dimethyl 1,4-cyclohexanedicarboxylate

Downstream raw materials:

1-(2-Chloro-ethyl)-3-(4-chloromethyl-cyclohexyl)-urea

C₁₁H₁₈ClN₃O₄

Refernces

• 1、 -. "NEW BICYCLIC DERIVATIVES HAVING BETA2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES". Page/Page column 44. . Retrieved 2016/04/20.
• 2、 -. "TRICYCLIC PYRROLOPYRIDINE COMPOUND, AND JAK INHIBITOR". Paragraph 0167; 0168. . Retrieved 2016/01/01.