(R,S)-[(4-chlorophenyl)-(2,5-dimethyl-2H-pyrazol-3-ylcarbamoyl)methyl]carbamic acid tert-butyl ester

Base Information

• Chemical Name: (R,S)-[(4-chlorophenyl)-(2,5-dimethyl-2H-pyrazol-3-ylcarbamoyl)methyl]carbamic acid tert-butyl ester
• CAS No.: 1201195-29-0
• Molecular Formula: C₁₈H₂₃ClN₄O₃
• Molecular Weight: 378.859
• Mol file: 1201195-29-0.mol

Synonyms:(R,S)-[(4-chlorophenyl)-(2,5-dimethyl-2H-pyrazol-3-ylcarbamoyl)methyl]carbamic acid tert-butyl ester

Chemical Property of (R,S)-[(4-chlorophenyl)-(2,5-dimethyl-2H-pyrazol-3-ylcarbamoyl)methyl]carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (R,S)-[(4-chlorophenyl)-(2,5-dimethyl-2H-pyrazol-3-ylcarbamoyl)methyl]carbamic acid tert-butyl ester

There total 1 articles about (R,S)-[(4-chlorophenyl)-(2,5-dimethyl-2H-pyrazol-3-ylcarbamoyl)methyl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

5-Amino-1,3-dimethylpyrazole (3524-32-1) + (±)-2-(tert-butoxycarbonyl)-2-(4-chlorophenyl)acetic Acid (53994-85-7) → (R,S)-[(4-chlorophenyl)-(2,5-dimethyl-2H-pyrazol-3-ylcarbamoyl)methyl]carbamic acid tert-butyl ester (1201195-29-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

Reference yield: 6.0%

(R,S)-[(4-chlorophenyl)-(2,5-dimethyl-2H-pyrazol-3-ylcarbamoyl)methyl]carbamic acid tert-butyl ester (1201195-29-0) + 2-[4-(trifluoromethyl)phenyl]ethyl bromide (130365-87-6) → (R,S)-2-amino-2-(4-chloro-phenyl)-N-(2,5-dimethyl-2H-pyrazol-3-yl)-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-acetamide (1201195-27-8)

Guidance literature:

(R,S)-[(4-chlorophenyl)-(2,5-dimethyl-2H-pyrazol-3-ylcarbamoyl)methyl]carbamic acid tert-butyl ester; 2-[4-(trifluoromethyl)phenyl]ethyl bromide; With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 20.5h;

With trifluoroacetic acid; at 20 ℃; for 3h;

upstream raw materials:

5-Amino-1,3-dimethylpyrazole

(±)-2-(tert-butoxycarbonyl)-2-(4-chlorophenyl)acetic Acid

Downstream raw materials:

(R,S)-2-amino-2-(4-chloro-phenyl)-N-(2,5-dimethyl-2H-pyrazol-3-yl)-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-acetamide