53994-85-7

Basic information

• Product Name: N-Boc-(4'-Chlorophenyl)glycine
• Synonyms: TERT-BUTOXYCARBONYLAMINO-(4-CHLORO-PHENYL)-ACETIC ACID;RARECHEM AK ML 0512;N-BOC-(4'-CHLOROPHENYL)GLYCINE;2-(TERTBUTOXYCARBONYLAMINO)-2-(4-CHLOROPHENYL)ACETIC ACID;N-BOC-2-(4''-CHLOROPHENYL)-D-GLYCINE;Benzeneacetic acid, 4-chloro-.alpha.-[[(1,1-dimethylethoxy)carbonyl]amino]-, (R)- (9CI);2-{[(tert-butoxy)carbonyl](4-chlorophenyl)aMino}acetic acid;(R)-2-((tert-Butoxycarbonyl)aMino)-2-(4-chlorophenyl)acetic acid
• CAS NO: 53994-85-7
• Molecular Formula: C₁₃H₁₆ClNO₄
• Molecular Weight: 285.72
• Mol File: 53994-85-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 438.8 °C at 760 mmHg
• Flash Point: 219.2 °C
• Appearance: /
• Density: 1.272g/cm³
• Storage Temp.: 2-8°C
• PKA: 3.38±0.10(Predicted)
• CAS DataBase Reference: N-Boc-(4'-Chlorophenyl)glycine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-(4'-Chlorophenyl)glycine(53994-85-7)
• EPA Substance Registry System: N-Boc-(4'-Chlorophenyl)glycine(53994-85-7)

Safety Data

• Hazardous Substances Data: 53994-85-7(Hazardous Substances Data)

Usage

General Description

N-Boc-(4'-Chlorophenyl)glycine, also referred to as tert-butyl ((4-chlorophenyl)amino)acetate, is a chemical compound with the molecular formula C13H16ClNO3. It is utilized in the field of organic synthesis where it is commonly employed as a building block or a reagent that enables the synthesis of more complex chemicals. Its presence of functional groups such as carboxylic esters and amines make it a valuable resource in the creation of a wide range of chemical substances. The N-Boc aspect indicates the presence of a protecting group for an amino acid, which is essential in peptide synthesis as it prevents unwanted side reactions.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 6212-33-5 2-(4-Chlorophenyl)glycine 
• 43189-37-3 (R)-2-amino-2-(4-chlorophenyl)acetic acid 
• 124-38-9 carbon dioxide 
• 1291065-80-9 C₂₄H₄₂ClNO₂Sn 
• 104-88-1 4-chlorobenzaldehyde 
• 774225-25-1 N-(tert-butoxycarbonyl)-α-(phenylsulfonyl)-4-chlorobenzylamine 
• 4248-19-5 tert-butyl carbazate 

Downstream Products

• 1097078-87-9 C₂₉H₂₉Cl₄N₃O₃ 
• 1171244-89-5 tert-butyl 1-(4-chlorophenyl)-2-hydrazinyl-2-oxoethylcarbamate 
• 1201195-29-0 (R,S)-[(4-chlorophenyl)-(2,5-dimethyl-2H-pyrazol-3-ylcarbamoyl)methyl]carbamic acid tert-butyl ester 
• 1201194-94-6 (R,S)-{(4-Chloro-phenyl)-[(5-methyl-thiazol-2-yl)-(2-p-tolyl-ethyl)-carbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 1201195-01-8 (R,S)-{(4-chloro-phenyl)-[(2,4-dimethyl-thiazol-5-yl)-(2-p-tolyl-ethyl)-carbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 1239902-83-0 C₂₃H₂₉BrClN₃O₄ 
• 1239902-82-9 C₁₉H₂₀BrClN₂O₃ 
• 1227360-90-8 C₁₈H₁₄ClN₅O 
• 1379514-53-0 (R)-quinuclidin-3-yl 2-benzamido-2-(4-chlorophenyl)acetate 
• 1379514-55-2 (3R)-3-(2-benzamido-2-(4-chlorophenyl)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate 
• 1379513-67-3 (3R)-3-(2-(tert-butoxycarbonylamino)-2-(4-chlorophenyl)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane bromide 
• 1379513-66-2 (R)-quinuclidin-3-yl 2-(tert-butoxycarbonylamino)-2-(4-chlorophenyl)acetate 

Relevant articles and documents

Synthesis ofN-Boc-α-amino Acids from Carbon Dioxide by Electrochemical Carboxylation ofN-Boc-α-aminosulfones

Electrochemical reduction ofN-Boc-α-aminosulfones in DMF using an undivided cell equipped with a Pt plate cathode and an Mg rod anode under atmospheric pressure of bubbling carbon dioxide through the solution under constant current conditions resulted in a reductive C-S bond cleavage with elimination of benzenesulfinate ion generating the corresponding anion species followed by fixation of carbon dioxide to give the correspondingN-Boc-α-amino acids in moderate to good yields.

Substituted p-chlorophenyl acetylpiperazine-containing compound as well as preparation method and application thereof

The application provides a substituted p-chlorophenyl acetylpiperazine-containing compound as well as a preparation method and application of the substituted p-chlorophenyl acetylpiperazine-containingcompound. The compound has the structure shown in the formula (I), and has better Akt1 inhibitory activity or growth inhibitory activity to MCL cell lines.

HETEROCYCLIC COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER

The present invention provides MDM2 inhibitor compounds of Formula I or II, or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.