Technology Process of methyl 3-(3,4-dihydroxyphenyl)-(2S)-2-((2E)-3-(4-hydroxyphenyl)acrylamido)propanoate
There total 3 articles about methyl 3-(3,4-dihydroxyphenyl)-(2S)-2-((2E)-3-(4-hydroxyphenyl)acrylamido)propanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethanolamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate;
In
dichloromethane; N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 16.5h;
- Guidance literature:
-
p-Coumaric Acid;
With
benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
at 20 ℃;
for 0.5h;
Inert atmosphere;
L-dopa methyl ester hydrochloride;
With
triethylammonium acetate;
In
dichloromethane; N,N-dimethyl-formamide;
at 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1248/bpb.b17-00303
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: thionyl chloride / 8 h / Reflux; Inert atmosphere
2.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere
2.2: 4 h / 20 °C / Inert atmosphere
With
thionyl chloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/bpb.b17-00303
