4-(4-methoxybenzoyl)-3-(3-phenylpropyl)-1-tosyl-1H-pyrrol-2(5H)-one

Base Information

• Chemical Name: 4-(4-methoxybenzoyl)-3-(3-phenylpropyl)-1-tosyl-1H-pyrrol-2(5H)-one
• CAS No.: 1437788-17-4
• Molecular Formula: C₂₈H₂₇NO₅S
• Molecular Weight: 489.592
• Mol file: 1437788-17-4.mol

Synonyms:4-(4-methoxybenzoyl)-3-(3-phenylpropyl)-1-tosyl-1H-pyrrol-2(5H)-one

Chemical Property of 4-(4-methoxybenzoyl)-3-(3-phenylpropyl)-1-tosyl-1H-pyrrol-2(5H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Technology Process of 4-(4-methoxybenzoyl)-3-(3-phenylpropyl)-1-tosyl-1H-pyrrol-2(5H)-one

There total 8 articles about 4-(4-methoxybenzoyl)-3-(3-phenylpropyl)-1-tosyl-1H-pyrrol-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

N-(3-(4-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(5-phenylpent-1-yn-1-yl)benzenesulfonamide (1437788-01-6) → 4-(4-methoxybenzoyl)-3-(3-phenylpropyl)-1-tosyl-1H-pyrrol-2(5H)-one (1437788-17-4) + C28H27NO4S (1437788-25-4)

Guidance literature:

With di(rhodium)tetracarbonyl dichloride; 3,5-dicholoropyridine N-oxide; tris(1,1,1,3,3,3-hexafluoroisopropyl)phosphite; In 1,4-dioxane; at 80 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ja4047069

Reference yield: 26.0%

N-(3-(4-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(5-phenylpent-1-yn-1-yl)benzenesulfonamide (1437788-01-6) → 4-(4-methoxybenzoyl)-3-(3-phenylpropyl)-1-tosyl-1H-pyrrol-2(5H)-one (1437788-17-4)

Guidance literature:

With 2,6-dichloropyridine N-oxide; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; In 1,2-dichloro-ethane; at 80 ℃; for 4h;

DOI:10.1002/cjoc.201800437

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 4-(4-methoxybenzoyl)-3-(3-phenylpropyl)-1-tosyl-1H-pyrrol-2(5H)-one (1437788-17-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 5 h / 20 °C

1.2: 2 h / 20 °C

2.1: 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; potassium carbonate / toluene / 36 h / 80 °C

3.1: 2,6-dichloropyridine N-oxide; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate / 1,2-dichloro-ethane / 4 h / 80 °C

With 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; 2,6-dichloropyridine N-oxide; potassium carbonate; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; triethylamine; In dichloromethane; 1,2-dichloro-ethane; toluene;

DOI:10.1002/cjoc.201800437

upstream raw materials:

N-(3-(4-methoxyphenyl)prop-2-yn-1-yl)-4-methyl-N-(5-phenylpent-1-yn-1-yl)benzenesulfonamide

para-iodoanisole

4-methyl-N-prop-2-ynylbenzenesulfonamide

N-[3-(4-methoxyphenyl)prop-2-yn-1-yl]-4-methylbenzenesulfonamide