2-<(1'S)-1'-hydroxy-1'-phenylpropyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin

Base Information

• Chemical Name: 2-<(1'S)-1'-hydroxy-1'-phenylpropyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin
• CAS No.: 89556-33-2
• Molecular Formula: C₂₀H₃₀O₂S
• Molecular Weight: 334.523
• Mol file: 89556-33-2.mol

Synonyms:2-<(1'S)-1'-hydroxy-1'-phenylpropyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin

Chemical Property of 2-<(1'S)-1'-hydroxy-1'-phenylpropyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<(1'S)-1'-hydroxy-1'-phenylpropyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin

There total 5 articles about 2-<(1'S)-1'-hydroxy-1'-phenylpropyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

ethylmagnesium bromide (925-90-6) + Phenyl-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-methanone (266694-57-9) → 2-<(1'S)-1'-hydroxy-1'-phenylpropyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin (89556-33-2)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -78 ℃; for 3h;

DOI:10.1021/ja00322a034

Reference yield: 69.0%

1-((2R,4aR,7R,8aR)-4,4,7-Trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-propan-1-one (79563-61-4) + phenylmagnesium bromide → 2-<(1'S)-1'-hydroxy-1'-phenylpropyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin (89556-33-2) + 2-<(1'R)-1'-hydroxy-1'-phenylpropyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin (142864-98-0)

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 4h; Title compound not separated from byproducts;

DOI:10.1021/jo00045a032

Reference yield:

(4aR,7R,8aR)-4,4,7-Trimethyl-hexahydro-1-oxa-3-thia-naphthalene (79618-03-4) → 2-<(1'S)-1'-hydroxy-1'-phenylpropyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin (89556-33-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / n-BuLi / tetrahydrofuran; hexane / -78 deg C, 2 h, -25 deg C, overnight

2: 1.) Me₂SO, (CF₃CO)2O; 2.) Et₃N / 1.) CH₂Cl₂, 1 h; 2.) 0 deg C

3: 73 percent / tetrahydrofuran; diethyl ether / 3 h / -78 °C

With n-butyllithium; dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; diethyl ether; hexane;

DOI:10.1021/ja00322a034

upstream raw materials:

ethylmagnesium bromide

Phenyl-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-methanone

1-((2R,4aR,7R,8aR)-4,4,7-Trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-propan-1-one

(4aR,7R,8aR)-4,4,7-Trimethyl-hexahydro-1-oxa-3-thia-naphthalene

Downstream raw materials:

(S)-(-)-2-phenyl-butane-1,2-diol

(3aR,6R,7aR)-3,3,6-Trimethyl-hexahydro-benzo[d][1,2]oxathiole 2-oxide

(S)-(-)-hydroxy-2-phenylbutanal

(S)-2-phenyl-butan-2-ol