Phenyl-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-methanone

Base Information

Chemical Name:Phenyl-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-methanone
CAS No.:266694-57-9
Molecular Formula:C₁₈H₂₄O₂S
Molecular Weight:304.453
Hs Code.:

Synonyms:Phenyl-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Phenyl-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Phenyl-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-methanone

There total 5 articles about Phenyl-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79618-03-4
(4aR,7R,8aR)-4,4,7-Trimethyl-hexahydro-1-oxa-3-thia-naphthalene

: 266694-57-9
Phenyl-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / n-BuLi / tetrahydrofuran; hexane / -78 deg C, 2 h, -25 deg C, overnight

2: 1.) Me₂SO, (CF₃CO)2O; 2.) Et₃N / 1.) CH₂Cl₂, 1 h; 2.) 0 deg C

With n-butyllithium; dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; hexane;
DOI:10.1021/ja00322a034

Reference yield:

: 79563-59-0
(-)-(1R,2R,5R)-5-methyl-2-(1-mercapto-1-methylethyl)-cyclohexan-1-ol

: 266694-57-9
Phenyl-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: 98.8 percent / p-toluenesulfonic acid / benzene / 3 h / Heating

2: 100 percent / n-BuLi / tetrahydrofuran; hexane / -78 deg C, 2 h, -25 deg C, overnight

3: 1.) Me₂SO, (CF₃CO)2O; 2.) Et₃N / 1.) CH₂Cl₂, 1 h; 2.) 0 deg C

With n-butyllithium; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; hexane; benzene;
DOI:10.1021/ja00322a034

Reference yield:

: Phenyl-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-methanol

: 266694-57-9
Phenyl-((2R,4aR,7R,8aR)-4,4,7-trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-methanone

Guidance literature:: With dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride; Yield given. Multistep reaction; 1.) CH₂Cl₂, 1 h; 2.) 0 deg C;
DOI:10.1021/ja00322a034