Technology Process of 4-benzyloxy-2-ethyl-3-methylbenzoic acid
There total 3 articles about 4-benzyloxy-2-ethyl-3-methylbenzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sec.-butyllithium / tetrahydrofuran / 0.5 h / -78 - -65 °C / Inert atmosphere
1.2: -78 °C
1.3: 0.5 h / Cooling with ice
2.1: boron tribromide / dichloromethane / 1 h / 20 °C / Inert atmosphere; Cooling with ice
2.2: Cooling with ice
3.1: potassium carbonate / acetone / 18 h / Reflux
3.2: 3 h / Reflux
3.3: 0.5 h / pH 1
With
sec.-butyllithium; boron tribromide; potassium carbonate;
In
tetrahydrofuran; dichloromethane; acetone;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: boron tribromide / dichloromethane / 1 h / 20 °C / Inert atmosphere; Cooling with ice
1.2: Cooling with ice
2.1: potassium carbonate / acetone / 18 h / Reflux
2.2: 3 h / Reflux
2.3: 0.5 h / pH 1
With
boron tribromide; potassium carbonate;
In
dichloromethane; acetone;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium chlorite; sodium dihydrogenphosphate / dimethyl sulfoxide / 1 h / 40 °C
2.1: sec.-butyllithium / tetrahydrofuran / 0.5 h / -78 - -65 °C / Inert atmosphere
2.2: -78 °C
2.3: 0.5 h / Cooling with ice
3.1: boron tribromide / dichloromethane / 1 h / 20 °C / Inert atmosphere; Cooling with ice
3.2: Cooling with ice
4.1: potassium carbonate / acetone / 18 h / Reflux
4.2: 3 h / Reflux
4.3: 0.5 h / pH 1
With
sodium chlorite; sodium dihydrogenphosphate; sec.-butyllithium; boron tribromide; potassium carbonate;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetone;
