2-ethyl-3-O-benzyl-17β-(2-methoxyethyl) 17-deoxyestrone

Base Information

Chemical Name:2-ethyl-3-O-benzyl-17β-(2-methoxyethyl) 17-deoxyestrone
CAS No.:767351-87-1
Molecular Formula:C₃₀H₄₀O₂
Molecular Weight:432.646
Hs Code.:

Synonyms:2-ethyl-3-O-benzyl-17β-(2-methoxyethyl) 17-deoxyestrone

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Chemical Property of 2-ethyl-3-O-benzyl-17β-(2-methoxyethyl) 17-deoxyestrone

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Technology Process of 2-ethyl-3-O-benzyl-17β-(2-methoxyethyl) 17-deoxyestrone

There total 4 articles about 2-ethyl-3-O-benzyl-17β-(2-methoxyethyl) 17-deoxyestrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 767351-86-0
2-ethyl-3-benzyloxy-17β-(2-hydroxyethyl)estra-1,3,5(10)-triene

: 74-88-4
methyl iodide

: 767351-87-1
2-ethyl-3-O-benzyl-17β-(2-methoxyethyl) 17-deoxyestrone

Guidance literature:: 2-ethyl-3-benzyloxy-17β-(2-hydroxyethyl)estra-1,3,5(10)-triene; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃; for 18h;

Reference yield:

: 767352-12-5
(3-benzyloxy-2-ethyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)-acetic acid ethyl ester

: 767351-87-1
2-ethyl-3-O-benzyl-17β-(2-methoxyethyl) 17-deoxyestrone

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

2.2: 2 h / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jm200483x

Reference yield:

: 767351-23-5
2-ethyl-3-hydroxy-17β-(2-ethoxy-2-oxoethyl)estra-1,3,5(10)-triene

: 767351-87-1
2-ethyl-3-O-benzyl-17β-(2-methoxyethyl) 17-deoxyestrone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

3.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

3.2: 2 h / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; sodium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm200483x