kukoamine B sulfate

Base Information

• Chemical Name: kukoamine B sulfate
• CAS No.: 1375179-93-3
• Molecular Formula: C₂₈H₄₂N₄O₆*H₂O₄S
• Molecular Weight: 628.744
• Mol file: 1375179-93-3.mol

Synonyms:kukoamine B sulfate

Chemical Property of kukoamine B sulfate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of kukoamine B sulfate

There total 13 articles about kukoamine B sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 4-(3-(3,4-bis(benzyloxy)phenyl)-N-(3-aminopropyl)propanamido)butyl(3-(3-(3,4-bis(benzyloxy)phenyl)propanamido)propyl)carbamate (1375180-15-6) → kukoamine B sulfate (1375179-93-3)

Guidance literature:

With sulfuric acid; palladium on activated charcoal; hydrogen; In tetrahydrofuran; methanol; water; at 45 ℃; under 75007.5 Torr; Autoclave;

Reference yield:

3-(3,4-bis(benzyloxy)phenyl)propanoyl chloride (1375180-06-5) → kukoamine B sulfate (1375179-93-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0 °C

2: ammonia; hydrogen / methanol; tetrahydrofuran / 50 °C / 7500.75 - 15001.5 Torr / Autoclave

3: hydrogen; palladium on activated charcoal; sulfuric acid / methanol; water; tetrahydrofuran / 45 °C / 75007.5 Torr / Autoclave

With sulfuric acid; palladium on activated charcoal; ammonia; hydrogen; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

dihydrocaffeic acid (1078-61-1) → kukoamine B sulfate (1375179-93-3)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

2: sodium hydroxide; water / methanol / 90 °C / Reflux

3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 5 h / 20 - 65 °C / Reflux

4: triethylamine / dichloromethane / 0 °C

5: ammonia; hydrogen / methanol; tetrahydrofuran / 50 °C / 7500.75 - 15001.5 Torr / Autoclave

6: hydrogen; palladium on activated charcoal; sulfuric acid / methanol; water; tetrahydrofuran / 45 °C / 75007.5 Torr / Autoclave

With thionyl chloride; sulfuric acid; palladium on activated charcoal; ammonia; water; hydrogen; potassium carbonate; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

N¹-tert-butoxycarbonyl-N⁴-(2-cyanoethyl)-1,4-butanediamine

N¹-benzyloxycarbonyl-N⁴-tert-butoxycarbonyl-N¹-(2-cyanoethyl)-1,4-butanediamine

N⁴-benzyloxycarbonyl-N⁸-tert-butoxycarbonylspermidine

3-(3,4-bis(benzyloxy)phenyl)propanoyl chloride

Refernces

• 1、 -. "SALTS OF KUKOAMINE B, PREPARATION METHOD AND USE THEREOF". . . Retrieved 2013/11/06.