1,1-dimethylethyl (3R)-3-{[3-(phenylsulfonyl)-8-quinolinyl]oxy}-1-pyrrolidinecarboxylate

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Chemical Name:1,1-dimethylethyl (3R)-3-{[3-(phenylsulfonyl)-8-quinolinyl]oxy}-1-pyrrolidinecarboxylate
CAS No.:866782-64-1
Molecular Formula:C₂₄H₂₆N₂O₅S
Molecular Weight:454.547
Hs Code.:

Synonyms:1,1-dimethylethyl (3R)-3-{[3-(phenylsulfonyl)-8-quinolinyl]oxy}-1-pyrrolidinecarboxylate

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Chemical Property of 1,1-dimethylethyl (3R)-3-{[3-(phenylsulfonyl)-8-quinolinyl]oxy}-1-pyrrolidinecarboxylate

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Technology Process of 1,1-dimethylethyl (3R)-3-{[3-(phenylsulfonyl)-8-quinolinyl]oxy}-1-pyrrolidinecarboxylate

There total 1 articles about 1,1-dimethylethyl (3R)-3-{[3-(phenylsulfonyl)-8-quinolinyl]oxy}-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 866782-60-7
8-fluoro-3-(phenylsulfonyl)quinoline

: 109431-87-0,83220-73-9
(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate

: 866782-64-1
1,1-dimethylethyl (3R)-3-{[3-(phenylsulfonyl)-8-quinolinyl]oxy}-1-pyrrolidinecarboxylate

Guidance literature:: (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate; With sodium hydride; In DMF (N,N-dimethyl-formamide); for 0.166667h;

8-fluoro-3-(phenylsulfonyl)quinoline; In DMF (N,N-dimethyl-formamide); at 60 ℃; for 16h;

Reference yield:

: 866782-64-1
1,1-dimethylethyl (3R)-3-{[3-(phenylsulfonyl)-8-quinolinyl]oxy}-1-pyrrolidinecarboxylate

: 3-(phenylsulfonyl)-8-[(3R)-3-pyrrolidinyloxy]quinoline hydrochloride

Guidance literature:: 1,1-dimethylethyl (3R)-3-{[3-(phenylsulfonyl)-8-quinolinyl]oxy}-1-pyrrolidinecarboxylate; With hydrogenchloride; In 1,4-dioxane; for 2h;

With hydrogenchloride; In methanol; diethyl ether;