Technology Process of (3R)-3-({[7-(2-methoxyphenyl)-1-benzofuran-2-yl]carbonyl}amino)-1-methyl-1-azoniabicyclo[2.2.2]octane chloride
There total 7 articles about (3R)-3-({[7-(2-methoxyphenyl)-1-benzofuran-2-yl]carbonyl}amino)-1-methyl-1-azoniabicyclo[2.2.2]octane chloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ABBF hydrochloride;
With
sodium hydride;
In
DMF (N,N-dimethyl-formamide);
at 20 ℃;
for 0.5h;
methyl iodide;
In
DMF (N,N-dimethyl-formamide);
at 20 ℃;
for 18h;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine; magnesium chloride / acetonitrile / 4 h / Heating / reflux
2.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / 6 h / 130 °C
2.2: 20 °C
3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / DMF (N,N-dimethyl-formamide); water / 18 h / 90 °C
4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / DMF (N,N-dimethyl-formamide) / 20 h / 20 - 55 °C
5.1: hydrogenchloride / methanol; water
6.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.5 h / 20 °C
6.2: 18 h / 20 °C
With
hydrogenchloride; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium carbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; magnesium chloride;
tetrakis(triphenylphosphine) palladium(0);
In
methanol; DMF (N,N-dimethyl-formamide); water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / DMF (N,N-dimethyl-formamide); water / 18 h / 90 °C
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / DMF (N,N-dimethyl-formamide) / 20 h / 20 - 55 °C
3.1: hydrogenchloride / methanol; water
4.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.5 h / 20 °C
4.2: 18 h / 20 °C
With
hydrogenchloride; sodium hydride; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
tetrakis(triphenylphosphine) palladium(0);
In
methanol; DMF (N,N-dimethyl-formamide); water;
