4-phenyl-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]-1-piperidinecarboxamide

Base Information

Chemical Name:4-phenyl-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]-1-piperidinecarboxamide
CAS No.:521070-59-7
Molecular Formula:C₂₆H₃₀N₄O
Molecular Weight:414.55
Hs Code.:

Synonyms:4-phenyl-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]-1-piperidinecarboxamide

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Chemical Property of 4-phenyl-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]-1-piperidinecarboxamide

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Technology Process of 4-phenyl-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]-1-piperidinecarboxamide

There total 7 articles about 4-phenyl-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]-1-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 521073-96-1
3-(1-pyrrolidinylmethyl)-7-quinolinylamine hydrochloride

: 10272-49-8
4-phenylpiperidine hydrochloride

: 530-62-1
1,1'-carbonyldiimidazole

: 521070-59-7
4-phenyl-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]-1-piperidinecarboxamide

Guidance literature:: 3-(1-pyrrolidinylmethyl)-7-quinolinylamine hydrochloride; 1,1'-carbonyldiimidazole; With triethylamine; In N,N-dimethyl acetamide; at 0 ℃; for 1h;

4-phenylpiperidine hydrochloride; In N,N-dimethyl acetamide; at 20 ℃; for 2h;
DOI:10.1021/jm201596h

Reference yield:

: 521073-96-1
3-(1-pyrrolidinylmethyl)-7-quinolinylamine hydrochloride

: 10272-49-8
4-phenylpiperidine hydrochloride

: 521070-59-7
4-phenyl-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]-1-piperidinecarboxamide

Guidance literature:: 3-(1-pyrrolidinylmethyl)-7-quinolinylamine hydrochloride; With triethylamine; 1,1'-carbonyldiimidazole; In ISOPROPYLAMIDE; at 0 ℃; for 1h;

4-phenylpiperidine hydrochloride; In ISOPROPYLAMIDE; at 0 - 30 ℃; for 2h;

Reference yield:

: 521073-92-7
N-[3-(hydroxymethyl)-7-quinolinyl]acetamide

: 521070-59-7
4-phenyl-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]-1-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 2 h / 20 °C

2.1: potassium carbonate / acetonitrile / 2 h / 80 °C

3.1: hydrogenchloride / 1 h / 100 °C

4.1: triethylamine / N,N-dimethyl acetamide / 1 h / 0 °C

4.2: 2 h / 20 °C

With hydrogenchloride; thionyl chloride; potassium carbonate; triethylamine; In N,N-dimethyl acetamide; acetonitrile;
DOI:10.1021/jm201596h