(S)-N-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-yl)-1-((S)3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)pyrrolidine-2-carboxamide hydrochloride

Base Information

Chemical Name:(S)-N-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-yl)-1-((S)3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)pyrrolidine-2-carboxamide hydrochloride
CAS No.:1363150-35-9
Molecular Formula:C₃₀H₃₆ClF₂N₇O₄*ClH
Molecular Weight:668.571
Hs Code.:

(S)-N-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-yl)-1-((S)3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)pyrrolidine-2-carboxamide hydrochloride

Synonyms:(S)-N-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-yl)-1-((S)3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)pyrrolidine-2-carboxamide hydrochloride

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Chemical Property of (S)-N-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-yl)-1-((S)3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)pyrrolidine-2-carboxamide hydrochloride

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Technology Process of (S)-N-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-yl)-1-((S)3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)pyrrolidine-2-carboxamide hydrochloride

There total 12 articles about (S)-N-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-yl)-1-((S)3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)pyrrolidine-2-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1363150-47-3
tert-butyl(S)-1-((S)-1-((S)-2-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)pyrrolidin-1-yl-3,3-dimethyl-1-oxobutan-2-ylamino)-1-oxopropan-2-yl)methylcarbamate

: 1363150-35-9
(S)-N-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-yl)-1-((S)3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)pyrrolidine-2-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1363150-35-9
(S)-N-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-yl)-1-((S)3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)pyrrolidine-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 4 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

6: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h

7: pyridine / 4 h / 60 °C

8: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With pyridine; hydrogenchloride; dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 762274-65-7
benzyl ((S)-2-((S)-2-((tert-butoxycarbonyl)(methyl)amino)propanamido)-3,3-dimethylbutanoyl)-L-prolinate

: 1363150-35-9
(S)-N-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-yl)-1-((S)3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)pyrrolidine-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h

2: pyridine / 4 h / 60 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With pyridine; hydrogenchloride; hydrogen; palladium 10% on activated carbon; In 1,4-dioxane; methanol;