tert-butyl(S)-1-((S)-1-((S)-2-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)pyrrolidin-1-yl-3,3-dimethyl-1-oxobutan-2-ylamino)-1-oxopropan-2-yl)methylcarbamate

Base Information

Chemical Name:tert-butyl(S)-1-((S)-1-((S)-2-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)pyrrolidin-1-yl-3,3-dimethyl-1-oxobutan-2-ylamino)-1-oxopropan-2-yl)methylcarbamate
CAS No.:1363150-47-3
Molecular Formula:C₃₅H₄₄ClF₂N₇O₆
Molecular Weight:732.227
Hs Code.:

tert-butyl(S)-1-((S)-1-((S)-2-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)pyrrolidin-1-yl-3,3-dimethyl-1-oxobutan-2-ylamino)-1-oxopropan-2-yl)methylcarbamate

Synonyms:tert-butyl(S)-1-((S)-1-((S)-2-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)pyrrolidin-1-yl-3,3-dimethyl-1-oxobutan-2-ylamino)-1-oxopropan-2-yl)methylcarbamate

Suppliers and Price of tert-butyl(S)-1-((S)-1-((S)-2-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)pyrrolidin-1-yl-3,3-dimethyl-1-oxobutan-2-ylamino)-1-oxopropan-2-yl)methylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl(S)-1-((S)-1-((S)-2-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)pyrrolidin-1-yl-3,3-dimethyl-1-oxobutan-2-ylamino)-1-oxopropan-2-yl)methylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl(S)-1-((S)-1-((S)-2-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)pyrrolidin-1-yl-3,3-dimethyl-1-oxobutan-2-ylamino)-1-oxopropan-2-yl)methylcarbamate

There total 10 articles about tert-butyl(S)-1-((S)-1-((S)-2-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)pyrrolidin-1-yl-3,3-dimethyl-1-oxobutan-2-ylamino)-1-oxopropan-2-yl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1363150-47-3
tert-butyl(S)-1-((S)-1-((S)-2-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)pyrrolidin-1-yl-3,3-dimethyl-1-oxobutan-2-ylamino)-1-oxopropan-2-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 4 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

6: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h

7: pyridine / 4 h / 60 °C

With pyridine; hydrogenchloride; dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 37787-77-2
Boc-L-proline benzyl ester

: 1363150-47-3
tert-butyl(S)-1-((S)-1-((S)-2-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)pyrrolidin-1-yl-3,3-dimethyl-1-oxobutan-2-ylamino)-1-oxopropan-2-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 4 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

5: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h

6: pyridine / 4 h / 60 °C

With pyridine; hydrogenchloride; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 16652-71-4
benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride

: 1363150-47-3
tert-butyl(S)-1-((S)-1-((S)-2-(4-(3-chloro-2,4-difluorophenylamino)-7-methoxyquinazolin-6-ylcarbamoyl)pyrrolidin-1-yl-3,3-dimethyl-1-oxobutan-2-ylamino)-1-oxopropan-2-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 4 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

4: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h

5: pyridine / 4 h / 60 °C

With pyridine; hydrogenchloride; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane;