4-(5-{2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamido}-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-{[bis(tert-butoxy)phosphoryl]oxymethyl}piperazin-1-ium

Base Information

Chemical Name:4-(5-{2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamido}-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-{[bis(tert-butoxy)phosphoryl]oxymethyl}piperazin-1-ium
CAS No.:1431216-68-0
Molecular Formula:C₃₉H₅₂F₆N₄O₅P
Molecular Weight:801.83
Hs Code.:

4-(5-{2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamido}-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-{[bis(tert-butoxy)phosphoryl]oxymethyl}piperazin-1-ium

Synonyms:4-(5-{2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamido}-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-{[bis(tert-butoxy)phosphoryl]oxymethyl}piperazin-1-ium

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Chemical Property of 4-(5-{2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamido}-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-{[bis(tert-butoxy)phosphoryl]oxymethyl}piperazin-1-ium

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Technology Process of 4-(5-{2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamido}-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-{[bis(tert-butoxy)phosphoryl]oxymethyl}piperazin-1-ium

There total 15 articles about 4-(5-{2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamido}-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-{[bis(tert-butoxy)phosphoryl]oxymethyl}piperazin-1-ium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 290297-26-6
netupitant

: 229625-50-7
di-tert-butyl chloromethyl phosphate

: 1431216-68-0
4-(5-{2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamido}-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-{[bis(tert-butoxy)phosphoryl]oxymethyl}piperazin-1-ium

Guidance literature:: With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In 1,2-dimethoxyethane; acetonitrile; at 50 - 90 ℃; for 12h;

Reference yield:

: 342417-02-1
[6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl]carbamic acid methyl ester

: 1431216-68-0
4-(5-{2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamido}-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-{[bis(tert-butoxy)phosphoryl]oxymethyl}piperazin-1-ium

Guidance literature:: Multi-step reaction with 3 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane; toluene / 2 h / 50 °C

2: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice

3: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dimethoxyethane; acetonitrile / 12 h / 50 - 90 °C

With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In 1,2-dimethoxyethane; dichloromethane; toluene; acetonitrile;

Reference yield:

: 5326-23-8
6-Chloro-3-pyridinecarboxylic acid

: 1431216-68-0
4-(5-{2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamido}-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-{[bis(tert-butoxy)phosphoryl]oxymethyl}piperazin-1-ium

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / tetrahydrofuran / 0 - 20 °C

1.2: 1.5 h / -60 - 20 °C

2.1: thionyl chloride / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 50 °C

2.2: 0.5 h / 0 °C

3.1: 2 h / 100 °C

4.1: N-Bromosuccinimide / methanol; dichloromethane / 16 h / -5 °C

4.2: 5.3 h / -5 °C

5.1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane; toluene / 2 h / 50 °C

6.1: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice

7.1: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1,2-dimethoxyethane; acetonitrile / 12 h / 50 - 90 °C

With N-Bromosuccinimide; thionyl chloride; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;