(3R,5S)-3,5-dimethyl-1-{(2R)-2-(1-hydroxycyclohexan-1-yl)-2-(3-trifluoromethoxyphenyl)acetyl} piperazine

Base Information

Chemical Name:(3R*,5S*)-3,5-dimethyl-1-{(2R)-2-(1-hydroxycyclohexan-1-yl)-2-(3-trifluoromethoxyphenyl)acetyl} piperazine
CAS No.:850618-86-9
Molecular Formula:C₂₁H₂₉F₃N₂O₃
Molecular Weight:414.468
Hs Code.:

Synonyms:(3R*,5S*)-3,5-dimethyl-1-{(2R)-2-(1-hydroxycyclohexan-1-yl)-2-(3-trifluoromethoxyphenyl)acetyl} piperazine

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Chemical Property of (3R*,5S*)-3,5-dimethyl-1-{(2R)-2-(1-hydroxycyclohexan-1-yl)-2-(3-trifluoromethoxyphenyl)acetyl} piperazine

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Technology Process of (3R*,5S*)-3,5-dimethyl-1-{(2R)-2-(1-hydroxycyclohexan-1-yl)-2-(3-trifluoromethoxyphenyl)acetyl} piperazine

There total 1 articles about (3R*,5S*)-3,5-dimethyl-1-{(2R)-2-(1-hydroxycyclohexan-1-yl)-2-(3-trifluoromethoxyphenyl)acetyl} piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1214914-36-9
C₁₅H₁₇F₃O₄

: 21655-48-1,1013625-96-1
cis-2,6-dimethylpiperazine

: 850618-86-9
(3R*,5S*)-3,5-dimethyl-1-{(2R)-2-(1-hydroxycyclohexan-1-yl)-2-(3-trifluoromethoxyphenyl)acetyl} piperazine

Guidance literature:: C₁₅H₁₇F₃O₄; With benzotriazol-1-ol; diisopropyl-carbodiimide; In tetrahydrofuran; tert-butyl methyl ether; at 1 - 19 ℃; for 1.5h;

cis-2,6-dimethylpiperazine; In tetrahydrofuran; tert-butyl methyl ether; water; at 5 - 20 ℃; for 2.5h;

Reference yield:

: 850618-86-9
(3R*,5S*)-3,5-dimethyl-1-{(2R)-2-(1-hydroxycyclohexan-1-yl)-2-(3-trifluoromethoxyphenyl)acetyl} piperazine

: 850692-43-2
(-)1-{(1S)-2-[(cis)-3,5-dimethylpiperazin-1-yl]-1-[3-(trifluoromethoxy)phenyl]ethyl} cyclohexanol

Guidance literature:: With aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 40 ℃;

(3R*,5S*)-3,5-dimethyl-1-{(2R)-2-(1-hydroxycyclohexan-1-yl)-2-(3-trifluoromethoxyphenyl)acetyl} piperazine; In tetrahydrofuran; at 8 - 20 ℃; for 3h;