trans-4-[(((S)-4,5-dichloro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzyl}-amino)-methyl]-cyclohexane-carboxylic acid hydrochloride

Base Information

Chemical Name:trans-4-[(((S)-4,5-dichloro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzyl}-amino)-methyl]-cyclohexane-carboxylic acid hydrochloride
CAS No.:1443019-58-6
Molecular Formula:C₃₁H₃₆Cl₂N₂O₆*ClH
Molecular Weight:640.004
Hs Code.:

trans-4-[(((S)-4,5-dichloro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzyl}-amino)-methyl]-cyclohexane-carboxylic acid hydrochloride

Synonyms:trans-4-[(((S)-4,5-dichloro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzyl}-amino)-methyl]-cyclohexane-carboxylic acid hydrochloride

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Chemical Property of trans-4-[(((S)-4,5-dichloro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzyl}-amino)-methyl]-cyclohexane-carboxylic acid hydrochloride

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Technology Process of trans-4-[(((S)-4,5-dichloro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzyl}-amino)-methyl]-cyclohexane-carboxylic acid hydrochloride

There total 6 articles about trans-4-[(((S)-4,5-dichloro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzyl}-amino)-methyl]-cyclohexane-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.1%

: 1443021-72-4
C₃₂H₃₈Cl₂N₂O₆

: 1443019-58-6
trans-4-[(((S)-4,5-dichloro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzyl}-amino)-methyl]-cyclohexane-carboxylic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 80 ℃; for 5h;

Reference yield:

: 121-33-5,8014-42-4
vanillin

: 1443019-58-6
trans-4-[(((S)-4,5-dichloro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzyl}-amino)-methyl]-cyclohexane-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 15 h / Reflux

2.1: sodium hydrogencarbonate / dichloromethane

2.2: 1.17 h / 15 - 20 °C

2.3: 1 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 5 h / 80 °C

With hydrogenchloride; sodium hydrogencarbonate; potassium carbonate; In 1,4-dioxane; dichloromethane; acetonitrile;

Reference yield:

: 55943-72-1
N-(2-bromoethyl)-succinimide

: 1443019-58-6
trans-4-[(((S)-4,5-dichloro-indan-1-yl)-{4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzyl}-amino)-methyl]-cyclohexane-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 15 h / Reflux

2.1: sodium hydrogencarbonate / dichloromethane

2.2: 1.17 h / 15 - 20 °C

2.3: 1 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 5 h / 80 °C

With hydrogenchloride; sodium hydrogencarbonate; potassium carbonate; In 1,4-dioxane; dichloromethane; acetonitrile;