3-[-3-[(2-aminophenyl)amino]-3-oxoprop-1-enyl]-N-[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]benzamide

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Chemical Name:3-[-3-[(2-aminophenyl)amino]-3-oxoprop-1-enyl]-N-[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]benzamide
CAS No.:1383622-80-7
Molecular Formula:C₃₅H₂₆F₃N₇O₂
Molecular Weight:633.632
Hs Code.:

Synonyms:3-[-3-[(2-aminophenyl)amino]-3-oxoprop-1-enyl]-N-[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]benzamide

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Chemical Property of 3-[-3-[(2-aminophenyl)amino]-3-oxoprop-1-enyl]-N-[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]benzamide

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Technology Process of 3-[-3-[(2-aminophenyl)amino]-3-oxoprop-1-enyl]-N-[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]benzamide

There total 8 articles about 3-[-3-[(2-aminophenyl)amino]-3-oxoprop-1-enyl]-N-[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383622-79-4
3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoic acid

: 95-54-5
1,2-diamino-benzene

: 1383622-80-7
3-[-3-[(2-aminophenyl)amino]-3-oxoprop-1-enyl]-N-[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]benzamide

Guidance literature:: 3-[3-[[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]carbamoyl]phenyl]prop-2-enoic acid; 1,2-diamino-benzene; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In acetonitrile; at 20 ℃; for 2h;

With sodium carbonate; In water; acetonitrile;

Reference yield:

: 22019-50-7
2-bromo-1-(4-methyl-3-nitrophenyl)ethanone

: 1383622-80-7
3-[-3-[(2-aminophenyl)amino]-3-oxoprop-1-enyl]-N-[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetonitrile / 18 h / Reflux

1.2: 1 h / 20 °C

2.1: potassium acetate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / butan-1-ol; water / 4 h / 90 °C

3.1: acetic acid; iron / ethanol / 60 - 70 °C

4.1: pyridine / acetonitrile / 18 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine / palladium diacetate / N,N-dimethyl-formamide / 18 h / 110 °C / Inert atmosphere; Sealed

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 50 °C

6.2: pH 2

7.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / acetonitrile / 2 h / 20 °C

With pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; potassium acetate; iron; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; sodium hydroxide; palladium diacetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;

Reference yield:

: 10397-30-5
4-methyl-3-nitrobenzoyl chloride

: 1383622-80-7
3-[-3-[(2-aminophenyl)amino]-3-oxoprop-1-enyl]-N-[2-methyl-5-[6-[2-(trifluoromethyl)-3-pyridyl]imidazo[2,1-f]pyridazin-2-yl]phenyl]benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: dichloromethane; hexane / 2 h / 20 °C

1.2: 0 °C

2.1: acetonitrile / 18 h / Reflux

2.2: 1 h / 20 °C

3.1: potassium acetate / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / butan-1-ol; water / 4 h / 90 °C

4.1: acetic acid; iron / ethanol / 60 - 70 °C

5.1: pyridine / acetonitrile / 18 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine / palladium diacetate / N,N-dimethyl-formamide / 18 h / 110 °C / Inert atmosphere; Sealed

7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 50 °C

7.2: pH 2

8.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / acetonitrile / 2 h / 20 °C

With pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; potassium acetate; iron; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; sodium hydroxide; palladium diacetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;