2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-N⁵-isopropylpyrimidine-4,5,6-triamine

Base Information

• Chemical Name: 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-N⁵-isopropylpyrimidine-4,5,6-triamine
• CAS No.: 1361570-55-9
• Molecular Formula: C₂₀H₂₁FN₈
• Molecular Weight: 392.439

Synonyms:2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-N⁵-isopropylpyrimidine-4,5,6-triamine

Chemical Property of 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-N⁵-isopropylpyrimidine-4,5,6-triamine

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Technology Process of 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-N⁵-isopropylpyrimidine-4,5,6-triamine

There total 1 articles about 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-N⁵-isopropylpyrimidine-4,5,6-triamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

acetone (67-64-1) + 2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6- triamine (428854-24-4) → 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-N5-isopropylpyrimidine-4,5,6-triamine (1361570-55-9)

Guidance literature:

With acetic acid; In methanol; at 20 ℃;

Reference yield:

2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-N5-isopropylpyrimidine-4,5,6-triamine (1361570-55-9) + 1,1'-carbonyldiimidazole (530-62-1) → 6-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7-isopropyl-7,9-dihydro-8H-purin-8-one (1361569-20-1)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 100 ℃;

Reference yield:

2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-N5-isopropylpyrimidine-4,5,6-triamine (1361570-55-9) → 2-[1-(2-fluorobenzyl)-1H-pyrazolo [3,4-b]pyridin-3-yl]-6-iodo-7-isopropyl-7,9-dihydro-8H-purin-8-one (1361569-90-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 100 °C

2: diiodomethane / dichloromethane

With diiodomethane; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

acetone

2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6- triamine

Downstream raw materials:

2-[1-(2-fluorobenzyl)-1H-pyrazolo [3,4-b]pyridin-3-yl]-6-iodo-7-isopropyl-7,9-dihydro-8H-purin-8-one

2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7-isopropyl-7,9-dihydro-8H-purin-8-one

6-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7-isopropyl-7,9-dihydro-8H-purin-8-one

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