tert-butyl 4-((1R,2R)-2-(((3,5-difluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((1R,2R)-2-(((3,5-difluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidine-1-carboxylate
CAS No.:1416364-78-7
Molecular Formula:C₂₂H₃₁F₂NO₅S
Molecular Weight:459.555
Hs Code.:

Synonyms:tert-butyl 4-((1R,2R)-2-(((3,5-difluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-((1R,2R)-2-(((3,5-difluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-((1R,2R)-2-(((3,5-difluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidine-1-carboxylate

There total 10 articles about tert-butyl 4-((1R,2R)-2-(((3,5-difluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1416366-42-1
tert-butyl 4-((1R,2R)-2-(((3,5-difluoro-4-(methylthio)benzyl)oxy)methyl)cyclopropyl)piperidine-1-carboxylate

: 1416364-78-7
tert-butyl 4-((1R,2R)-2-(((3,5-difluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidine-1-carboxylate

Guidance literature:: With m-chloroperoxybenzoic acid; In dichloromethane; at 20 ℃;

Reference yield:

: 403802-41-5
tert-butyl 4-(3-hydroxyprop-1-yn-1-yl)piperidine-1-carboxylate

: 1416364-78-7
tert-butyl 4-((1R,2R)-2-(((3,5-difluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; quinoline / Lindlar's catalyst / ethyl acetate / 0.67 h / 760.05 Torr

2.1: diethylzinc / dichloromethane; 1,2-dimethoxyethane / 1.58 h / -30 - -20 °C / Inert atmosphere

2.2: 1 h / -15 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 0 °C

3.2: 0 - 20 °C

4.1: m-chloroperoxybenzoic acid / dichloromethane / 20 °C

With quinoline; m-chloroperoxybenzoic acid; hydrogen; diethylzinc; sodium hydride; Lindlar's catalyst; In 1,2-dimethoxyethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 132123-54-7
3,4,5-trifluorobenzaldehyde

: 1416364-78-7
tert-butyl 4-((1R,2R)-2-(((3,5-difluoro-4-(methylsulfonyl)benzyl)oxy)methyl)cyclopropyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethyl sulfoxide / 0.28 h / 125 °C / Microwave irradiation

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 0 °C

2.2: 0 - 20 °C

3.1: m-chloroperoxybenzoic acid / dichloromethane / 20 °C

With m-chloroperoxybenzoic acid; sodium hydride; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;