(3R,5S,6R)-3-benzyl-5-<(tert-butyldimethylsilyl)oxy>-6-<(2-phenyl)ethyl>piperidin-2-one

Base Information

Chemical Name:(3R,5S,6R)-3-benzyl-5-<(tert-butyldimethylsilyl)oxy>-6-<(2-phenyl)ethyl>piperidin-2-one
CAS No.:227095-36-5
Molecular Formula:C₂₆H₃₇NO₂Si
Molecular Weight:423.671
Hs Code.:

Synonyms:(3R,5S,6R)-3-benzyl-5-<(tert-butyldimethylsilyl)oxy>-6-<(2-phenyl)ethyl>piperidin-2-one

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Chemical Property of (3R,5S,6R)-3-benzyl-5-<(tert-butyldimethylsilyl)oxy>-6-<(2-phenyl)ethyl>piperidin-2-one

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Technology Process of (3R,5S,6R)-3-benzyl-5-<(tert-butyldimethylsilyl)oxy>-6-<(2-phenyl)ethyl>piperidin-2-one

There total 1 articles about (3R,5S,6R)-3-benzyl-5-<(tert-butyldimethylsilyl)oxy>-6-<(2-phenyl)ethyl>piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: (E/Z)-(3R,5S,6R)-3-benzyl-5-<(tert-butyldimethylsilyl)oxy>-6-<(2-phenyl)ethen-1-yl>piperidin-2-one

: 227095-36-5
(3R,5S,6R)-3-benzyl-5-<(tert-butyldimethylsilyl)oxy>-6-<(2-phenyl)ethyl>piperidin-2-one

Guidance literature:: With hydrogen; sodium acetate; palladium on activated charcoal; In tetrahydrofuran; for 24h; Ambient temperature;
DOI:10.1016/S0957-4166(99)00051-8

Reference yield:

: 227095-36-5
(3R,5S,6R)-3-benzyl-5-<(tert-butyldimethylsilyl)oxy>-6-<(2-phenyl)ethyl>piperidin-2-one

: (3R,5S,6R)-1,3-dibenzyl-5-hydroxy-6-<(2-phenyl)ethyl>piperidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 2 h

2: 92 percent / HCl / ethanol / 5 h / Ambient temperature

With hydrogenchloride; sodium hydride; In ethanol;
DOI:10.1016/S0957-4166(99)00051-8

Reference yield:

: 100-39-0
benzyl bromide

: 227095-36-5
(3R,5S,6R)-3-benzyl-5-<(tert-butyldimethylsilyl)oxy>-6-<(2-phenyl)ethyl>piperidin-2-one

: 227780-33-8
(3R,5S,6R)-1,3-Dibenzyl-5-(tert-butyl-dimethyl-silanyloxy)-6-phenethyl-piperidin-2-one

Guidance literature:: With sodium hydride; Yield given; Multistep reaction; 1.) DMF, RT, 30 min, 2.) DMF, RT, 2 h;
DOI:10.1016/S0957-4166(99)00051-8