3-(4-METHYL-6-OXO-2-PHENYL-1,6-DIHYDROPYRIMIDIN-5-YL)PROPANOIC ACID

Base Information

• Chemical Name: 3-(4-METHYL-6-OXO-2-PHENYL-1,6-DIHYDROPYRIMIDIN-5-YL)PROPANOIC ACID
• CAS No.: 21506-68-3
• Molecular Formula: C14H14 N2 O3
• Molecular Weight: 258.277
• Hs Code.: 2933599090
• Mol file: 21506-68-3.mol

Synonyms:5-Pyrimidinepropanoicacid, 1,4-dihydro-6-methyl-4-oxo-2-phenyl- (9CI); 5-Pyrimidinepropionic acid,4-hydroxy-6-methyl-2-phenyl- (8CI)

Chemical Property of 3-(4-METHYL-6-OXO-2-PHENYL-1,6-DIHYDROPYRIMIDIN-5-YL)PROPANOIC ACID

Chemical Property:

• Vapor Pressure: 4.46E-09mmHg at 25°C
• Refractive Index: 1.617
• Boiling Point: 455.2°Cat760mmHg
• Flash Point: 229.1°C
• PSA: 83.31000
• Density: 1.28g/cm³
• LogP: 2.17480

Purity/Quality:

97% ^*data from raw suppliers

3-(4-METHYL-6-OXO-2-PHENYL-1,6-DIHYDROPYRIMIDIN-5-YL)PROPANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-METHYL-6-OXO-2-PHENYL-1,6-DIHYDROPYRIMIDIN-5-YL)PROPANOIC ACID

There total 2 articles about 3-(4-METHYL-6-OXO-2-PHENYL-1,6-DIHYDROPYRIMIDIN-5-YL)PROPANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl 2-acetylglutarate (1501-06-0) + benzamidine monohydrochloride (1670-14-0) → 3-(4-methyl-6-oxo-2-phenyl-1,6-dihydropyrimidin-5-yl)propanoic acid (21506-68-3)

Guidance literature:

With sodium hydroxide; Aufbewahren des entstandenen Aethylesters in Natronlauge;

Reference yield:

→ 3-(4-methyl-6-oxo-2-phenyl-1,6-dihydro-pyrimidin-5-yl)-propionic acid (21506-68-3)

Guidance literature:

entspr. Ethylester 1. KOH 2. H⁺;

DOI:10.1021/jm00303a019

Reference yield: 89.0%

3-(4-methyl-6-oxo-2-phenyl-1,6-dihydropyrimidin-5-yl)propanoic acid (21506-68-3) + 2-amino-phenol (95-55-6) → 5-[2-(1,3-benzoxazol-2-yl)ethyl]-4-methyl-2-phenylpyrimidin-4(3H)-one

Guidance literature:

With polyphosphoric acid; at 230 - 240 ℃; for 4h;

DOI:10.1134/S1070428015030112

upstream raw materials:

diethyl 2-acetylglutarate

benzamidine monohydrochloride

Downstream raw materials:

4-methyl-2-phenyl-5,6-dihydrobenzo[4',5']imidazo[1',2':1,6]pyrido[2,3-d]pyrimidine