4-nitro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide

Base Information

• Chemical Name: 4-nitro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide
• CAS No.: 1310058-64-0
• Molecular Formula: C₁₈H₁₈N₆O₃S
• Molecular Weight: 398.445

Synonyms:4-nitro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide

Chemical Property of 4-nitro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide

Chemical Property:

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Technology Process of 4-nitro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide

There total 3 articles about 4-nitro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

C15H10ClN5O3S (1310058-63-9) + isopropylamine (75-31-0) → 4-nitro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide (1310058-64-0)

Guidance literature:

With potassium carbonate; In 1,4-dioxane; at 20 - 80 ℃;

DOI:10.1016/j.bmcl.2011.03.046

Reference yield:

4-(6-chloropyrimidin-4-yl)-N-methylthiazol-2-amine (932738-80-2) → 4-nitro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide (1310058-64-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / toluene / 2 h / 100 °C

2: potassium carbonate / 1,4-dioxane / 20 - 80 °C

With potassium carbonate; triethylamine; In 1,4-dioxane; toluene;

DOI:10.1016/j.bmcl.2011.03.046

Reference yield:

4-nitro-benzoyl chloride (122-04-3) → 4-nitro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide (1310058-64-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / toluene / 2 h / 100 °C

2: potassium carbonate / 1,4-dioxane / 20 - 80 °C

With potassium carbonate; triethylamine; In 1,4-dioxane; toluene;

DOI:10.1016/j.bmcl.2011.03.046

upstream raw materials:

4-(6-chloropyrimidin-4-yl)-N-methylthiazol-2-amine

C₁₅H₁₀ClN₅O₃S

isopropylamine

4-nitro-benzoyl chloride

Downstream raw materials:

4-[18F]fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide

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