4-(3,4-difluoro-phenyl)-4,6-dimethyl-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester

Base Information

• Chemical Name: 4-(3,4-difluoro-phenyl)-4,6-dimethyl-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester
• CAS No.: 1446679-84-0
• Molecular Formula: C₁₇H₁₅F₂N₃O₂S
• Molecular Weight: 363.388
• Mol file: 1446679-84-0.mol

Synonyms:4-(3,4-difluoro-phenyl)-4,6-dimethyl-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester

Chemical Property of 4-(3,4-difluoro-phenyl)-4,6-dimethyl-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3,4-difluoro-phenyl)-4,6-dimethyl-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester

There total 13 articles about 4-(3,4-difluoro-phenyl)-4,6-dimethyl-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

1,3-thiazole-2-carboximidamide hydrochloride (247037-82-7) + C13H12F2O3 → 4-(3,4-difluoro-phenyl)-4,6-dimethyl-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester (1446679-84-0)

Guidance literature:

With sodium hydrogencarbonate; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 3h;

Reference yield: 55.0%

methyl 2-acetyl-3-(3,4-difluorophenyl)but-2-enoate (1446680-75-6) + thiazole-2-carboximidamide hydrochloride → 4-(3,4-difluoro-phenyl)-4,6-dimethyl-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester (1446679-84-0)

Guidance literature:

With sodium hydrogencarbonate; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 3h;

Reference yield:

methyl 6-chloro-4-(3,4-difluorophenyl)-4-methyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (1446680-73-4) + tetramethylstannane (594-27-4) → 4-(3,4-difluoro-phenyl)-4,6-dimethyl-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester (1446679-84-0)

Guidance literature:

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 140 ℃; for 0.5h; Microwave irradiation; Inert atmosphere;

upstream raw materials:

4-ethynyl-1,2-difluorobenzene

C₁₃H₁₂F₂O₄

methyl 4-(3,4-difluorophenyl)-4-methyl-6-oxo-2-(thiazol-2-yl)-1,4,5,6-tetrahydropyrimidine-5-carboxylate

methyl 6-chloro-4-(3,4-difluorophenyl)-4-methyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

Downstream raw materials:

(R)-4-(3,4-difluoro-phenyl)-4,6-dimethyl-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester

(S)-4-(3,4-difluoro-phenyl)-4,6-dimethyl-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester