247037-82-7

Basic information

• Product Name: 2-Thiazolecarboxamidine Hydrochloride
• Synonyms: 2-Thiazolecarboxamidine Hydrochloride;2-ThiazolecarboxiMidaMide hydrochloride;1,3-thiazole-2-carboxiMidaMide hydrochloride;Thiazole-2-carboxiMidaMide hydrochloride;2-ThiazolecarboxiMidaMide HCl;2-Thiazolecarboximidamide, hydrochloride (1:1);2-Thiazolecarboxamidine,HCl;Thiazole-2-carboxamidine hydrochloride
• CAS NO: 247037-82-7
• Molecular Formula: C₄H₅N₃S*ClH
• Molecular Weight: 164
• Product Categories: Clinical hepatitis b&c drug intermediates
• Mol File: 247037-82-7.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-Thiazolecarboxamidine Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiazolecarboxamidine Hydrochloride(247037-82-7)
• EPA Substance Registry System: 2-Thiazolecarboxamidine Hydrochloride(247037-82-7)

Safety Data

• Hazardous Substances Data: 247037-82-7(Hazardous Substances Data)

Usage

General Description

2-Thiazolecarboxamidine hydrochloride is a chemical compound that is used mainly as a reagent in chemical synthesis. It is a derivative of thiazole, which is a five-membered heterocyclic ring containing sulfur and nitrogen atoms. The hydrochloride salt form of 2-thiazolecarboxamidine is stable and soluble in water, making it suitable for various synthetic applications. It is commonly used as a starting material for the preparation of other thiazole-based compounds, as well as in the pharmaceutical industry for the development of potential drug candidates. Additionally, 2-thiazolecarboxamidine hydrochloride has been utilized in research settings for its ability to interact with biological targets and demonstrate antimicrobial and antiparasitic properties.

Upstream product

• 1452-16-0 thiazole-2-carbonitrile 

Downstream Products

• 1040736-07-9 C₁₇H₁₃ClFN₃OS 
• 1040736-06-8 C₁₉H₁₇ClFN₃OS 
• 247037-77-0 4-(2-chloro-4-fluoro-phenyl)-6-methyl-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester 
• 247037-78-1 ethyl 4-(2-chloro-4-fluorophenyl)-6-methyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate 

Relevant articles and documents

CRYSTAL FORM, PREPARATION METHOD AND INTERMEDIATE OF DIHYDROPYRIDO RING COMPOUND

Disclosed in the present disclosure are a crystal form of a dihydropyrido ring compound, and preparation method and intermediate thereof.

Design, Synthesis, and Evaluation of Tetrahydropyrrolo[1,2-c]pyrimidines as Capsid Assembly Inhibitors for HBV Treatment

The discovery of novel tetrahydropyrrolo[1,2-c]pyrimidines derivatives from Bay41-4109 as hepatitis B virus (HBV) inhibitors is herein reported. The structure-activity relationship optimization led to one highly efficacious compound 28a (IC50 = 10 nM) with good PK profiles and the favorite L/P ratio. The hydrodynamic injection model in mice clearly demonstrated the efficacy of 28a against HBV replication.

Design and synthesis of orally bioavailable 4-methyl heteroaryldihydropyrimidine based hepatitis B virus (HBV) capsid inhibitors

Targeting the capsid protein of hepatitis B virus (HBV) and thus interrupting normal capsid formation have been an attractive approach to block the replication of HBV viruses. We carried out multidimensional structural optimizations based on the heteroaryldihydropyrimidine (HAP) analogue Bay41-4109 (1) and identified a novel series of HBV capsid inhibitors that demonstrated promising cellular selectivity indexes, metabolic stabilities, and in vitro safety profiles. Herein we disclose the design, synthesis, structureactivity relationship (SAR), cocrystal structure in complex with HBV capsid proteins and in vivo pharmacological study of the 4-methyl HAP analogues. In particular, the (2S,4S)-4,4-difluoroproline substituted analogue 34a demonstrated high oral bioavailability and liver exposure and achieved over 2 log viral load reduction in a hydrodynamic injected (HDI) HBV mouse model.