tert-butyl 4-[2-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]piperazinecarboxylate

Base Information

Chemical Name:tert-butyl 4-[2-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]piperazinecarboxylate
CAS No.:252950-32-6
Molecular Formula:C₂₆H₃₁Cl₂N₉O₄
Molecular Weight:604.496
Hs Code.:

Synonyms:tert-butyl 4-[2-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]piperazinecarboxylate

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Chemical Property of tert-butyl 4-[2-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]piperazinecarboxylate

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Technology Process of tert-butyl 4-[2-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]piperazinecarboxylate

There total 6 articles about tert-butyl 4-[2-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: amino{2-[(5-nitro(pyridin-2-yl))amino]-ethyl}-carboxamidine

: tert-butyl 4-{2-(2,4-dichlorophenyl)-1-[(dimethylamino)methylene]-2-oxoethyl}piperazinecarboxylate

: 252950-32-6
tert-butyl 4-[2-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]piperazinecarboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide;

Reference yield:

: N-[2-(6-amino-5-nitropyridin-2-ylamino)ethyl]guanidine

: C₂₀H₂₇Cl₂N₃O₃

: 252950-32-6
tert-butyl 4-[2-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]piperazinecarboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 14h;
DOI:10.1021/acs.jmedchem.7b00922

Reference yield:

: tert-butyl 4-(2-(2,4-dichlorophenyl)-2-oxoethyl)piperazine-1-carboxylate

: 252950-32-6
tert-butyl 4-[2-({2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}amino)-4-(2,4-dichlorophenyl)pyrimidin-5-yl]piperazinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 6 h / 80 °C

2: caesium carbonate / N,N-dimethyl-formamide / 14 h / 90 °C

With caesium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.7b00922