2-benzyl-1,1-dioxo-3-(2-oxo-propyl)-6-trifluoromethyl-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide

Base Information

• Chemical Name: 2-benzyl-1,1-dioxo-3-(2-oxo-propyl)-6-trifluoromethyl-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide
• CAS No.: 3754-11-8
• Molecular Formula: C₁₈H₁₈F₃N₃O₅S₂
• Molecular Weight: 477.485

Synonyms:2-benzyl-1,1-dioxo-3-(2-oxo-propyl)-6-trifluoromethyl-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide

Chemical Property of 2-benzyl-1,1-dioxo-3-(2-oxo-propyl)-6-trifluoromethyl-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide

Chemical Property:

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Technology Process of 2-benzyl-1,1-dioxo-3-(2-oxo-propyl)-6-trifluoromethyl-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide

There total 3 articles about 2-benzyl-1,1-dioxo-3-(2-oxo-propyl)-6-trifluoromethyl-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-oxobutyraldehyde (625-34-3) + 4-amino-6-trifluoromethyl-benzene-1,3-disulfonic acid 1-amide 3-benzylamide (2836-79-5) → 2-benzyl-1,1-dioxo-3-(2-oxo-propyl)-6-trifluoromethyl-1,2,3,4-tetrahydro-1λ6-benzo[1,2,4]thiadiazine-7-sulfonic acid amide (3754-11-8)

Guidance literature:

With hydrogenchloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm00325a018

Reference yield:

1,1,3-trioxo-6-trifluoromethyl-1,2,3,4-tetrahydro-1λ6-benzo[1,2,4]thiadiazine-7-sulfonic acid amide (447-82-5) → 2-benzyl-1,1-dioxo-3-(2-oxo-propyl)-6-trifluoromethyl-1,2,3,4-tetrahydro-1λ6-benzo[1,2,4]thiadiazine-7-sulfonic acid amide (3754-11-8)

Guidance literature:

Multi-step reaction with 3 steps

1: (benzylation)

2: (alkaline hydrolysis)

3: aq. HCl / dimethylformamide

With hydrogenchloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm00325a018

Reference yield:

2-benzyl-1,1,3-trioxo-6-trifluoromethyl-1,2,3,4-tetrahydro-1λ6-benzo[1,2,4]thiadiazine-7-sulfonic acid amide (2250-74-0) → 2-benzyl-1,1-dioxo-3-(2-oxo-propyl)-6-trifluoromethyl-1,2,3,4-tetrahydro-1λ6-benzo[1,2,4]thiadiazine-7-sulfonic acid amide (3754-11-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (alkaline hydrolysis)

2: aq. HCl / dimethylformamide

With hydrogenchloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm00325a018

upstream raw materials:

3-oxobutyraldehyde

4-amino-6-trifluoromethyl-benzene-1,3-disulfonic acid 1-amide 3-benzylamide

1,1,3-trioxo-6-trifluoromethyl-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide

2-benzyl-1,1,3-trioxo-6-trifluoromethyl-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide

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