methyl 3-[(3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]benzoate

Base Information

Chemical Name:methyl 3-[(3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]benzoate
CAS No.:1418295-79-0
Molecular Formula:C₂₂H₁₈F₄N₂O₃
Molecular Weight:434.39
Hs Code.:

Synonyms:methyl 3-[(3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]benzoate

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Chemical Property of methyl 3-[(3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]benzoate

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 3-[(3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]benzoate

There total 9 articles about methyl 3-[(3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1418296-92-0
3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazole

: 1129-28-8
3-methoxycarbonylbenzyl bromide

: 1418295-79-0
methyl 3-[(3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]benzoate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

Reference yield:

: 4027-57-0
ethyl 5-methyl-1H-pyrazole-3-carboxylate

: 1418295-79-0
methyl 3-[(3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]benzoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 16 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

4.1: N,N-dimethyl-formamide / 1 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

6.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

6.2: 16 h / -78 - 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 - 5 °C

8.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

9.1: potassium tert-butylate / tetrahydrofuran / 16 h / 0 - 20 °C

With hydrogenchloride; potassium tert-butylate; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1418296-88-4
ethyl 5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxylate

: 1418295-79-0
methyl 3-[(3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]benzoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

3.1: N,N-dimethyl-formamide / 1 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

5.2: 16 h / -78 - 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 - 5 °C

7.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

8.1: potassium tert-butylate / tetrahydrofuran / 16 h / 0 - 20 °C

With hydrogenchloride; potassium tert-butylate; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;