3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazole

Base Information

Chemical Name:3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazole
CAS No.:1418296-92-0
Molecular Formula:C₁₃H₁₀F₄N₂O
Molecular Weight:286.229
Hs Code.:

Synonyms:3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazole

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Chemical Property of 3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazole

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Technology Process of 3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazole

There total 8 articles about 3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₁₈F₄N₂O₂

: 1418296-92-0
3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazole

: 1418296-93-1
3-{(E)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazole

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 16h;

Reference yield:

: 4027-57-0
ethyl 5-methyl-1H-pyrazole-3-carboxylate

: 1418296-92-0
3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazole

: 1418296-93-1
3-{(E)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 16 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

4.1: N,N-dimethyl-formamide / 1 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

6.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

6.2: 16 h / -78 - 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 - 5 °C

8.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

With hydrogenchloride; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1418296-88-4
ethyl 5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxylate

: 1418296-92-0
3-{(Z)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazole

: 1418296-93-1
3-{(E)-1-fluoro-2-[4-(trifluoromethoxy)phenyl]vinyl}-5-methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

3.1: N,N-dimethyl-formamide / 1 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

5.2: 16 h / -78 - 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 - 5 °C

7.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

With hydrogenchloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;