2,2'-[(oxybis(methylene))bis(5-methyl-[1,1'-biphenyl]-3',2-diyl)]bis(oxy)bis(tetrahydro-2H-pyran)

Base Information

Chemical Name:2,2'-[(oxybis(methylene))bis(5-methyl-[1,1'-biphenyl]-3',2-diyl)]bis(oxy)bis(tetrahydro-2H-pyran)
CAS No.:1312236-76-2
Molecular Formula:C₃₈H₄₂O₅
Molecular Weight:578.748
Hs Code.:

Synonyms:2,2'-[(oxybis(methylene))bis(5-methyl-[1,1'-biphenyl]-3',2-diyl)]bis(oxy)bis(tetrahydro-2H-pyran)

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Chemical Property of 2,2'-[(oxybis(methylene))bis(5-methyl-[1,1'-biphenyl]-3',2-diyl)]bis(oxy)bis(tetrahydro-2H-pyran)

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Technology Process of 2,2'-[(oxybis(methylene))bis(5-methyl-[1,1'-biphenyl]-3',2-diyl)]bis(oxy)bis(tetrahydro-2H-pyran)

There total 3 articles about 2,2'-[(oxybis(methylene))bis(5-methyl-[1,1'-biphenyl]-3',2-diyl)]bis(oxy)bis(tetrahydro-2H-pyran) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 938083-09-1
3,3'-[oxybis(methylene)]bis(bromobenzene)

: 114212-23-6
2-(2-bromo-4-methylphenoxy)-tetrahydro-2H-pyran

: 1312236-76-2
2,2'-[(oxybis(methylene))bis(5-methyl-[1,1'-biphenyl]-3',2-diyl)]bis(oxy)bis(tetrahydro-2H-pyran)

Guidance literature:: 2-(2-bromo-4-methylphenoxy)-tetrahydro-2H-pyran; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

With zinc(II) chloride; In tetrahydrofuran; hexane; for 1h;

3,3'-[oxybis(methylene)]bis(bromobenzene); With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; for 2h; Reflux;
DOI:10.1021/ja2021312

Reference yield:

: 15852-73-0
(3-Bromophenyl)methanol

: 1312236-76-2
2,2'-[(oxybis(methylene))bis(5-methyl-[1,1'-biphenyl]-3',2-diyl)]bis(oxy)bis(tetrahydro-2H-pyran)

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C

1.2: 12 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: 1 h

2.3: 2 h / Reflux

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; mineral oil; 2.1: Negishi cross-coupling / 2.2: Negishi cross-coupling / 2.3: Negishi cross-coupling;
DOI:10.1021/ja2021312

Reference yield:

: 823-78-9
meta-bromobenzyl bromide

: 1312236-76-2
2,2'-[(oxybis(methylene))bis(5-methyl-[1,1'-biphenyl]-3',2-diyl)]bis(oxy)bis(tetrahydro-2H-pyran)

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C

1.2: 12 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: 1 h

2.3: 2 h / Reflux

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; mineral oil; 2.1: Negishi cross-coupling / 2.2: Negishi cross-coupling / 2.3: Negishi cross-coupling;
DOI:10.1021/ja2021312