3-{2-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)propanamide

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Chemical Name:3-{2-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)propanamide
CAS No.:1421848-25-0
Molecular Formula:C₂₆H₃₄N₄O₃S
Molecular Weight:482.647
Hs Code.:

Synonyms:3-{2-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)propanamide

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Chemical Property of 3-{2-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)propanamide

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Technology Process of 3-{2-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)propanamide

There total 11 articles about 3-{2-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.9%

: 1421848-24-9
(2E)-3-{2-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)prop-2-enamide

: 1421848-25-0
3-{2-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)propanamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 14h; under 760.051 Torr;

Reference yield:

: 1245207-16-2
ethyl 1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazole-4-carboxylate

: 1421848-25-0
3-{2-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)propanamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 1 h / 20 °C

2.1: thionyl chloride / toluene / 2.5 h / 100 °C

2.2: 14 h / 20 °C

3.1: Lawessons reagent / tetrahydrofuran / 0.33 h / 60 °C

4.1: ethanol / 14 h / 90 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

6.1: sulfur trioxide pyridine complex / dimethyl sulfoxide / 14 h / 20 °C

7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 - 20 °C

7.2: 5 h / 0 - 20 °C

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 0 - 60 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 14 h / 20 °C

10.1: palladium 10% on activated carbon; hydrogen / methanol / 14 h / 20 °C / 760.05 Torr

With Lawessons reagent; lithium aluminium tetrahydride; thionyl chloride; palladium 10% on activated carbon; water; hydrogen; sulfur trioxide pyridine complex; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 2881-83-6
ethyl 4-methoxybenzoylacetate

: 1421848-25-0
3-{2-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)propanamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: toluene / 14 h / 90 °C

1.2: 20 h / 80 °C

2.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 1 h / 20 °C

3.1: thionyl chloride / toluene / 2.5 h / 100 °C

3.2: 14 h / 20 °C

4.1: Lawessons reagent / tetrahydrofuran / 0.33 h / 60 °C

5.1: ethanol / 14 h / 90 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

7.1: sulfur trioxide pyridine complex / dimethyl sulfoxide / 14 h / 20 °C

8.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 - 20 °C

8.2: 5 h / 0 - 20 °C

9.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 0 - 60 °C

10.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 14 h / 20 °C

11.1: palladium 10% on activated carbon; hydrogen / methanol / 14 h / 20 °C / 760.05 Torr

With Lawessons reagent; lithium aluminium tetrahydride; thionyl chloride; palladium 10% on activated carbon; water; hydrogen; sulfur trioxide pyridine complex; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;