(2E)-3-{2-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)prop-2-enamide

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Chemical Name:(2E)-3-{2-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)prop-2-enamide
CAS No.:1421848-24-9
Molecular Formula:C₂₆H₃₂N₄O₃S
Molecular Weight:480.631
Hs Code.:

Synonyms:(2E)-3-{2-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)prop-2-enamide

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Chemical Property of (2E)-3-{2-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)prop-2-enamide

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Technology Process of (2E)-3-{2-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)prop-2-enamide

There total 10 articles about (2E)-3-{2-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)prop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.7%

: 130290-79-8
4-tetrahydropyranmethylamine

: 1421850-07-8
(E)-3-(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acrylic acid

: 1421848-24-9
(2E)-3-{2-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)prop-2-enamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

Reference yield:

: 1245207-16-2
ethyl 1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazole-4-carboxylate

: 1421848-24-9
(2E)-3-{2-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)prop-2-enamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 1 h / 20 °C

2.1: thionyl chloride / toluene / 2.5 h / 100 °C

2.2: 14 h / 20 °C

3.1: Lawessons reagent / tetrahydrofuran / 0.33 h / 60 °C

4.1: ethanol / 14 h / 90 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

6.1: sulfur trioxide pyridine complex / dimethyl sulfoxide / 14 h / 20 °C

7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 - 20 °C

7.2: 5 h / 0 - 20 °C

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 0 - 60 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 14 h / 20 °C

With Lawessons reagent; lithium aluminium tetrahydride; thionyl chloride; water; sulfur trioxide pyridine complex; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 2881-83-6
ethyl 4-methoxybenzoylacetate

: 1421848-24-9
(2E)-3-{2-[1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}-N-(tetrahydro-2H-pyran-4-ylmethyl)prop-2-enamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: toluene / 14 h / 90 °C

1.2: 20 h / 80 °C

2.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 1 h / 20 °C

3.1: thionyl chloride / toluene / 2.5 h / 100 °C

3.2: 14 h / 20 °C

4.1: Lawessons reagent / tetrahydrofuran / 0.33 h / 60 °C

5.1: ethanol / 14 h / 90 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

7.1: sulfur trioxide pyridine complex / dimethyl sulfoxide / 14 h / 20 °C

8.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 - 20 °C

8.2: 5 h / 0 - 20 °C

9.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 0 - 60 °C

10.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 14 h / 20 °C

With Lawessons reagent; lithium aluminium tetrahydride; thionyl chloride; water; sulfur trioxide pyridine complex; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;