9-hydroxy-8-methyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione

Base Information

Chemical Name:9-hydroxy-8-methyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione
CAS No.:82635-61-8
Molecular Formula:C₁₃H₁₄N₂O₃
Molecular Weight:246.266
Hs Code.:

Synonyms:9-hydroxy-5,11-dioxo-8-methyl-2,3,5,10,11,11a-hexahydro-1H-pyrrolo<2,1-c><1,4>benzodiazepine

Suppliers and Price of 9-hydroxy-8-methyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 9-hydroxy-8-methyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione

Chemical Property:

Vapor Pressure:4.29E-12mmHg at 25°C

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

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Technology Process of 9-hydroxy-8-methyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione

There total 7 articles about 9-hydroxy-8-methyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.4%

: 78205-49-9
9-benzyloxy-8-methyl-5,11-dioxo-2,3,4,10,11,11a-hexahydro-1H-pyrrolo<2,1-c><1,4>benzodiazepine

: 82635-61-8
9-hydroxy-5,11-dioxo-8-methyl-2,3,5,10,11,11a-hexahydro-1H-pyrrolo<2,1-c><1,4>benzodiazepine

Guidance literature:: With hydrogen; palladium on activated charcoal; Ambient temperature;

Reference yield:

: 7536-35-8
2-nitro-3-benzyloxy-4-methylbenzoyl chloride

: 82635-61-8
9-hydroxy-5,11-dioxo-8-methyl-2,3,5,10,11,11a-hexahydro-1H-pyrrolo<2,1-c><1,4>benzodiazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 60.7 percent / triethylamine / CH₂Cl₂ / 1 h

2: 1. sodium dithionite, 2. aq. HCl / 1. 50percent aq. THF

3: 89.4 percent / H₂ / 10percent Pd/C / Ambient temperature

With hydrogenchloride; sodium dithionite; hydrogen; triethylamine; palladium on activated charcoal; In dichloromethane;

Reference yield:

: 33305-75-8,131477-20-8
L-proline ethyl ester monohydrochloride

: 82635-61-8
9-hydroxy-5,11-dioxo-8-methyl-2,3,5,10,11,11a-hexahydro-1H-pyrrolo<2,1-c><1,4>benzodiazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 60.7 percent / triethylamine / CH₂Cl₂ / 1 h

2: 1. sodium dithionite, 2. aq. HCl / 1. 50percent aq. THF

3: 89.4 percent / H₂ / 10percent Pd/C / Ambient temperature

With hydrogenchloride; sodium dithionite; hydrogen; triethylamine; palladium on activated charcoal; In dichloromethane;