benzyl-carbamic acid 4-[3,3-dimethyl-2-(2-methylamino-propionylamino)-butyryl]-1-isopropylcarbamoyl-octahydro-pyrrolo[3,2-b]pyrrol-3-yl ester

Base Information

Chemical Name:benzyl-carbamic acid 4-[3,3-dimethyl-2-(2-methylamino-propionylamino)-butyryl]-1-isopropylcarbamoyl-octahydro-pyrrolo[3,2-b]pyrrol-3-yl ester
CAS No.:1257233-99-0
Molecular Formula:C₂₈H₄₄N₆O₅
Molecular Weight:544.695
Hs Code.:

benzyl-carbamic acid 4-[3,3-dimethyl-2-(2-methylamino-propionylamino)-butyryl]-1-isopropylcarbamoyl-octahydro-pyrrolo[3,2-b]pyrrol-3-yl ester

Synonyms:benzyl-carbamic acid 4-[3,3-dimethyl-2-(2-methylamino-propionylamino)-butyryl]-1-isopropylcarbamoyl-octahydro-pyrrolo[3,2-b]pyrrol-3-yl ester

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Chemical Property of benzyl-carbamic acid 4-[3,3-dimethyl-2-(2-methylamino-propionylamino)-butyryl]-1-isopropylcarbamoyl-octahydro-pyrrolo[3,2-b]pyrrol-3-yl ester

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Technology Process of benzyl-carbamic acid 4-[3,3-dimethyl-2-(2-methylamino-propionylamino)-butyryl]-1-isopropylcarbamoyl-octahydro-pyrrolo[3,2-b]pyrrol-3-yl ester

There total 25 articles about benzyl-carbamic acid 4-[3,3-dimethyl-2-(2-methylamino-propionylamino)-butyryl]-1-isopropylcarbamoyl-octahydro-pyrrolo[3,2-b]pyrrol-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1257235-51-0
{1-[1-(6-benzylcarbamoyloxy-4-isopropylcarbamoyl-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl)-2,2-dimethyl-propylcarbamoyl]-ethyl}-methyl-carbamic acid benzyl ester

: 1257233-99-0
benzyl-carbamic acid 4-[3,3-dimethyl-2-(2-methylamino-propionylamino)-butyryl]-1-isopropylcarbamoyl-octahydro-pyrrolo[3,2-b]pyrrol-3-yl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 3.5h;

Reference yield:

: 1245724-76-8
N-Boc-4R-O-TBS-2R-aminoethyl-pyrrolidine

: 1257233-99-0
benzyl-carbamic acid 4-[3,3-dimethyl-2-(2-methylamino-propionylamino)-butyryl]-1-isopropylcarbamoyl-octahydro-pyrrolo[3,2-b]pyrrol-3-yl ester

Guidance literature:: Multi-step reaction with 20 steps

1.1: dichloromethane / 0 - 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C

3.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 0 - 20 °C

4.1: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C

5.1: borane / tetrahydrofuran / -30 - 0 °C

5.2: -10 - 0 °C

6.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 0 °C

7.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h

8.1: sodium acetate / 85 - 90 °C

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

10.1: pyridine hydrogenfluoride / tetrahydrofuran / 0 - 20 °C

11.1: di-isopropyl azodicarboxylate; triphenylphosphine / benzene / 20 °C

12.1: sodium hydroxide / tetrahydrofuran; methanol / 0 °C

13.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 0 - 20 °C

14.1: triethylamine / dichloromethane / 0 °C

15.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h

16.1: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 0 °C

17.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

18.1: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 0 °C

19.1: acetonitrile / Reflux

20.1: hydrogen / palladium 10% on activated carbon / methanol / 3.5 h

With hydrogenchloride; di-isopropyl azodicarboxylate; borane; tetrabutyl ammonium fluoride; hydrogen; sodium acetate; sodium hexamethyldisilazane; sulfur trioxide pyridine complex; pyridine hydrogenfluoride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; sodium hydroxide; dmap; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; dimethyl sulfoxide; acetonitrile; benzene;

Reference yield:

: 648930-90-9
(-)-(3S,3aS,6aR)-3-hydroxyhexahydropyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester

: 1257233-99-0
benzyl-carbamic acid 4-[3,3-dimethyl-2-(2-methylamino-propionylamino)-butyryl]-1-isopropylcarbamoyl-octahydro-pyrrolo[3,2-b]pyrrol-3-yl ester

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogenchloride / 1,4-dioxane; dichloromethane / 0 - 20 °C

2: triethylamine / dichloromethane / 0 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 3 h

4: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 0 °C

5: hydrogen / palladium 10% on activated carbon / methanol / 2 h

6: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 0 °C

7: acetonitrile / Reflux

8: hydrogen / palladium 10% on activated carbon / methanol / 3.5 h

With hydrogenchloride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; acetonitrile;