Ethyl 6-Methyl-3-oxo-2,3-dihydropyridazine-4-carboxylate

Base Information

• Chemical Name: Ethyl 6-Methyl-3-oxo-2,3-dihydropyridazine-4-carboxylate
• CAS No.: 2125-90-8
• Molecular Formula: C8H10 N2 O3
• Molecular Weight: 182.179
• Hs Code.: 2933990090
• Mol file: 2125-90-8.mol

Synonyms:Ethyl 6-Methyl-3-oxo-2,3-dihydropyridazine-4-carboxylate

Chemical Property of Ethyl 6-Methyl-3-oxo-2,3-dihydropyridazine-4-carboxylate

Chemical Property:

• Melting Point: 117℃
• PSA: 72.05000
• Density: 1.28±0.1 g/cm3 (20 ºC 760 Torr)
• LogP: 0.25500

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl 6-methyl-3-oxo-2,3-dihydropyridazine-4-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 6-Methyl-3-oxo-2,3-dihydropyridazine-4-carboxylate

There total 3 articles about Ethyl 6-Methyl-3-oxo-2,3-dihydropyridazine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

ethyl 3-methyl-6-oxo-4,5-dihydro-1H-pyridazine-5-carboxylate (98489-92-0) → ethyl 3-methyl-6-oxo-1H-pyridazine-5-carboxylate (2125-90-8)

Guidance literature:

With bromine; acetic acid; at 20 ℃; for 1h;

Reference yield:

diethyl 2-(2-oxopropyl)malonate (23193-18-2) → ethyl 3-methyl-6-oxo-1H-pyridazine-5-carboxylate (2125-90-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 16 h / 0 - 20 °C

2: acetic acid; bromine / 1 h / 20 °C

With bromine; hydrazine hydrate; acetic acid; In ethanol;

Reference yield:

→ ethyl 3-methyl-6-oxo-1H-pyridazine-5-carboxylate (2125-90-8)

Guidance literature:

3-Methyl-pyridazon-(6)-carbonsaeure-(5), konz. H2SO4, abs. EtOH, Sieden (Ausb. 70percent);

upstream raw materials:

diethyl 2-(2-oxopropyl)malonate

ethyl 3-methyl-6-oxo-4,5-dihydro-1H-pyridazine-5-carboxylate

Downstream raw materials:

2-[{2-(3,4-dimethoxyphenyl)-2,3-dihydro-6-methyl-3-oxo-4-pyridazinyl}carbonyl]-1,3-cyclohexanedione

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